Types of constitutional diatheses in children with tuberculosis infection

Abstract

Diathesis or constitutional abnormality is a polygenically inherited tendency of an organism to diseases, objectively recognized by deviations from the normal phenotype. There are 4 types of diatheses: exudative-catarrhal, lymphatic-hypoplastic, neuro-arthritic and allergic. The aim of the work was to identify and determine the frequency of diathesis in children with different course of tuberculosis infection. 225 children aged from 1 to 14 years were examined: 108 children with active forms of tuberculosis; 54 children with residual post-tuberculosis changes; 63 children with latent tuberculosis infection. It was found that among patients with active tuberculosis, children with lymphatic-hypoplastic (17.6 ± 3.7%) and neuro-arthritic diathesis (16.7 ± 3.6%) are most common, and children with allergic diathesis (11.1 ± 3.0% of cases) are less common. Children with lymphatic-hypoplastic diathesis often develop a complicated course of tuberculosis (26.3 ± 10.1%), there is a pronounced intoxication syndrome (58.0± 11.3%). The frequency of occurrence of children with allergic diathesis is higher in patients with residual post-tuberculosis changes (29.6 ± 6.2%) and with latent tuberculosis infection (33.3 ± 6.0%) than in patients with active tuberculosis (11.1 ± 3.0%)