Diagnostic performance of C-reactive protein and D-dimer test in acute varicothrombophlebitis
DOI:
https://doi.org/10.52692/1857-0011.2021.3-71.38Keywords:
D-dimer, C-reactive protein, acute varicothrombophlebitisAbstract
Diagnostic value of C-reactive protein (CRP) and D-dimer test in acute varicothrombophlebitis (VTP) was studied in a cohort of 45 patients; female – 60%, median age – 59 (25-75% IQR 48-64) years. In patients with normal value of CRP the rate of VTP type II-III (Verrel-Steckmeier) was 4% vs 25% – in those with CRP ≥10 mg/L; while the thrombus growth rate was 2 times lower – 2.33 (25-75% IQR 0.74-8.18) cm3/day and 5.74 (25-75% IQR 1.82-15.02) cm3/day, respectively (P=0.07 in both cases). A larger area of skin hyperemia and soft tissue perivenous infiltrate were identified in patients with CRP ≥10 mg/L vs normal values of CRP: 153.2 (25-75% IQR 49.35-248.8) vs 48.4 (25-75% IQR 40.45-85.7) cm2 and 86.25 (25-75% IQR 26.08-131.3) vs 32.35 (25-75% IQR 17.95-52.33) cm2, P=0.05 and 0.06, respectively. The level of D-dimers in types II-III of VTP exceeded the respective index in cases of type I of VTP and isolated thrombosis of varicose tributaries: 876 (25-75% IQR 611-1637) ng/mL vs 395 (25-75% IQR 216-710) ng/mL (p<0.05). Analysis of the ROC curve demonstrated an optimal cut-off value for the exclusion of types II-III of acute VTP equal to 611 ng/mL (sensitivity = 85.7%; specificity = 65.7%). Negative predictive value of the model – 95.8% (95% CI 73.6-98.1).References
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