Assessment of the effectiveness of sympathetic nervous system inhibitation through various therapeutic regimes on nictemeral variability of blood pressure and circadian profile in patients with resistant hypertension

Abstract

Despite administration of various drug treatment regimens leaves a large proportion of patients with resistant hyperten- sion with uncontrolled blood pressure values, who are at increased risk for cardiovascular and renal complications. Recognition of the major role of the sympathetic nervous system in the pathogenesis of hypertension has led to the development of new minimally invasive methods, which reduce the activity of the sympathetic nervous system at the peripheral renal level, resulting in reduced blood pressure. One such treatment is renal artery denervation - an innovative method devised 10 years ago that involves disrupting afferent and efferent renal sympathetic fibers by applying radiofrequency energy.In this way, we aimed to conduct an open-label clinical study that will assess the effectiveness of blocking the sympathetic nervous system through various therapeutic regimens on blood pressure variability and diurnal profile in patients with resistant hypertension. The data obtained demonstrated the antihypertensive effectiveness of both pharmacological and interventional treatment, but renal denervation having a much higher impact.