The benefit of antiinflammation treatment via IL-10 in diverse experimental models of heart failure

Authors

  • POPOVICI Mihail IMSP Institutul de cardiologie
  • MUNTEANU Mihaela IMSP Institutul de cardiologie
  • POPOVICI Ion IMSP Institutul de cardiologie
  • IVANOV Victoria IMSP Institutul de cardiologie
  • CIOBANU Lucia IMSP Institutul de cardiologie
  • MORARU Ion IMSP Institutul de cardiologie
  • ROTARU Victoria Universitatea de Stat de Medicină și Farmacie „Nicolae Testemițanu”
  • TACU Lilia Universitatea de Stat de Medicină și Farmacie „Nicolae Testemițanu”
  • TODIRAȘ Mihail Universitatea de Stat de Medicină și Farmacie „Nicolae Testemițanu”
  • COBEȚ Valeriu Universitatea de Stat de Medicină și Farmacie „Nicolae Testemițanu”

DOI:

https://doi.org/10.52692/1857-0011.2022.1-72.11

Keywords:

heart failure, IL-10, model of isolated heart perfusion, functional benefit

Abstract

Aim. The in vitro estimation of IL-10 effects in diverse experimental models of heart failure (HF). Material and methods. HF was induced in rats either by Dx administration in cumulative dose of 16 mg/kg or by isoproterenol administration twice in dose of 150 mg/kg. IL-10 was i/p administration daily during 7 days after HF modeling in single dose of 50 mkg/kg. Functional effects were assayed using perfused isolated heart exposed to hemodynamic and neuroendocrine efforts. Results. IL-10 improved in a similar manner in both HF models capacity of the heart regarding its adaptation to effort by volume and resistance, the most important tool being increasing of isovolumic relaxation and contraction velocity by up to 19%. Noteworthy, IL-10 led to appearance of positive inotropic effect on ET-1 action associated with cardiac output enhancement. Likewise, IL-10 augmented myocardium tolerance to ischemia and reperfusion action according to significant lesser levels of the left ventricle end diastolic pressure. Finally, IL-10 increased coronary functional reserve inherent to acetylcholine action, and coronary flow raised by 25-33% during parasympathetic stimulation. Conclusion. IL-10 notably improves analogically the functional performances of the heart in various models of experimental heart failure during hemodynamic and neuroendocrine efforts, underlying that inflammation is an important pathogenic factor of HF regardless of myocardial injury kind.

Author Biographies

POPOVICI Mihail, IMSP Institutul de cardiologie

prof. univ., dr. hab. șt. med., academician al AȘM,

MUNTEANU Mihaela, IMSP Institutul de cardiologie

doctorand

POPOVICI Ion, IMSP Institutul de cardiologie

dr. hab. șt. med., prof. cercetător

IVANOV Victoria, IMSP Institutul de cardiologie

dr. hab. șt. med., prof. cercetător

CIOBANU Lucia, IMSP Institutul de cardiologie

dr. hab. șt. med., conf. cercetător

MORARU Ion, IMSP Institutul de cardiologie

dr. șt. med., conf. cercetător

ROTARU Victoria, Universitatea de Stat de Medicină și Farmacie „Nicolae Testemițanu”

dr. șt. med., conf. univ.,

TACU Lilia, Universitatea de Stat de Medicină și Farmacie „Nicolae Testemițanu”

asistent univ.,

TODIRAȘ Mihail, Universitatea de Stat de Medicină și Farmacie „Nicolae Testemițanu”

dr. hab. șt. med., conf. univ.,

COBEȚ Valeriu, Universitatea de Stat de Medicină și Farmacie „Nicolae Testemițanu”

dr. hab. șt. med., prof. univ

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Published

2022-04-08