Circadian rhythm disruptions and neurodegeneration through Parkinson disease and cognitive disruptions.


  • Madalina CEBUC Universitatea de Stat de Medicină și Farmacie „Nicolae Testemițanu”
  • Lilia ROTARU Institutul de Neurologie și Neurochirurgie „D. Gherman”
  • Adrian LUPUSHOR State University of Medicine and Pharmacy "N. Testemițanu"; Institute of Neurology and Neurosurgery "D. German"
  • Ion MOLDOVANU State University of Medicine and Pharmacy "N. Testemițanu"; Institute of Neurology and Neurosurgery "D. German"
  • Oxana GROSU Institute of Neurology and Neurosurgery "D. German"
  • Ghenadie CARAUSHU State University of Medicine and Pharmacy "N. Testemițanu"
  • Victor VOVC State University of Medicine and Pharmacy "N. Testemițanu"; Institute of Neurology and Neurosurgery "D. German"



circadian rhythm disorders, Parkinson disease, cognitive disruption, neurodegenerative diseases, dementia, circadian clock, CLOCK genes


Circadian rhythm disorders (CRD) result from modern lifestyles characterized by long exposure time to blue light, shift-work, chronic stress and night-time social activities. The disruption of circadian rhythms represents an individual risk factor in the development of various diseases, including neurodegenerative ones. Simultaneously, the demographic ageing is associated with the rising incidence of neurodegenerative diseases (ND), the cognitive decline becoming a societal problem. Thus, this literature review’s purpose is to outline the interconnexion between CRD – ND – cognitive disruptions from a pathophysiological angle based on the example of Parkinson disease. The final objective of the study is to depict what are the prophylactic measures against brain and cognitive reserve’s decline caused by CRD in order to enhance life quality by lowering the DALY index.


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Research Article