NETosis and non-ST elevation acute myocardial infarction: pathophysiological significance and circulating markers

Authors

  • Mihail POPOVICI IMSP Institutul de Cardiologie
  • Victoria IVANOV IMSP Institutul de Cardiologie
  • Ion POPOVICI IMSP Institutul de Cardiologie
  • Lucia CIOBANU IMSP Institutul de Cardiologie
  • Mihaela MUNTEANU doctor în științe medicale, cercetător științific
  • Ion MORARU IMSP Institutul de Cardiologie
  • POPOVICI Ion IMSP Institutul de Cardiologie
  • COBEȚ Valeriu IP Universitatea de Stat de Medicină și Farmacie „Nicolae Testemițanu”

DOI:

https://doi.org/10.52692/1857-0011.2023.1-75.02

Keywords:

NETosis, NSTEMI, circulating markers

Abstract

Purpose. Evaluation of the role of neutrophil death (NET-osis) in the evolution of non-ST-segment elevation myocardial infarction (NSTEMI) by assessing circulating levels of in-patient admission of markers that are pathophysiologically related to this phenomenon. Material and methods. The research was carried out on a group of 54 patients with NSTEMI, undergoing coronary angioplasty in the laboratory of interventional cardiology within the scientific project of the State Program, in which the serum content of 7 biochemical markers was determined by the ELISA method: Selectin E, the molecule of intercellular adhesion 1 (ICAM-1), phospholipase 2 (PhA2), interleukin 8 (IL-8), neutrophil elastase (EN), myeloperoxidase (MPO) and metalloproteinase 8 (MMP-8). The control group consisted of 30 apparently healthy people. Results. The obtained results indicate the presence of significant incremental deviations of all explored markers in patients with NSTEMI compared to the control. The more specific markers of NETosis (MPO, NE and MMP-8) had a highest raising ratio, detected in a range of 88-151%. The other markers had a rate of circulating levels increase in a range of 50-74%. Conclusion. The admission circulating levels of specific markers of NETosis, myeloperoxidase, neutrophil elastase and MMP-8 are elevated in patients with NSTEMI by 88-151% compared to control, evidence, that indicates the pathogenetic role of NETosis as well as the plausible diagnostical and prognostical value of these markers.

Author Biographies

Mihail POPOVICI, IMSP Institutul de Cardiologie

dr. hab. șt. medicale, prof. universitar, academician al AȘM.

Victoria IVANOV, IMSP Institutul de Cardiologie

doctor habilitat în științe medicale, prof. cercetător

Ion POPOVICI, IMSP Institutul de Cardiologie

doctor habilitat în științe medicale, prof. cercetător

Lucia CIOBANU, IMSP Institutul de Cardiologie

doctor habilitat în științe medicale, conf. cercetător

Mihaela MUNTEANU, doctor în științe medicale, cercetător științific

doctor în științe medicale, cercetător științific

Ion MORARU, IMSP Institutul de Cardiologie

doctor în științe medicale, conf. cercetător

POPOVICI Ion, IMSP Institutul de Cardiologie

student medicinist, anul VI

COBEȚ Valeriu, IP Universitatea de Stat de Medicină și Farmacie „Nicolae Testemițanu”

doctor habilitat în științe medicale, prof. universitar

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Published

2023-06-01

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Research Article

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