Endothelial dysfunction in patients with non-ST-segment elevation myocardial infarction


  • Olga DICUSAR IMSP Institutul de Cardiologie
  • Victoria IVANOV IMSP Institutul de Cardiologie
  • Petru LIUBA
  • Mihail POPOVICI IMSP Institutul de Cardiologie




endothelial dysfunction, non-ST-segment elevation myocardial infarction, EndoPat 2000


Purpose: Evaluation of peripheral endothelial function using EndoPAT 2000 device in patients with non-ST-eleva-tion myocardial infarction (NSTEMI) and correlation with clinical characteristics of the patients.Material and methods: The study included 39 patients with NSTEMI, hospitalized in 2 PCI centers, in the period 03.2022-03.2023. At 72 hours after admission, peripheral endothelial function was assessed using the EndoPAT 2000 device. Patients were divided into 2 groups according to the presence of peripheral endothelial dysfunction (RHI <1.67). Statistical analysis of the data was performed using the t-test and the χ2 test. Results: The average value of the reactive hyperemia index (RHI) was 1.73 ± 0.47. Endothelial dysfunction was diag- nosed in 51,3% of NSTEMI patients. Group I included 19 patients with normal endothelial function (RHI>1.67), and group II – 20 patients with endothelial dysfunction (RHI<1.67). In the group of patients with endothelial dysfunction, twoor three-vessel disease prevailed (χ2=2.7, p=0.43) and a higher rate of coronary angioplasty was recorded (χ2=4.36, p=0.037). Conclusion: Peripheral endothelial dysfunction estimated by the EndoPat 2000 method is identified in 51,3% of patients with NSTEMI. The endothelial dysfunction correlated with severity of coronary lesions. Further studies are neededto assess the diagnostic and prognostic value of the method.

Author Biographies

Olga DICUSAR, IMSP Institutul de Cardiologie

cercetător științific

Victoria IVANOV , IMSP Institutul de Cardiologie

doctor habilitat în științe medicale, prof. cercetător

Mihail POPOVICI , IMSP Institutul de Cardiologie

dr. hab. șt. medicale, prof. universitar, academician al AȘM.


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Research Article