Acute phase proteins in patients with recurrent pulmonary tuberculosis
DOI:
https://doi.org/10.52692/1857-0011.2023.3-77.13Keywords:
tuberculosis, relapse, leukocytes, complement factors C3 and C4, haptoglobin, ceruloplasmin, properdin, C-reactive protein, IL-6, ESRAbstract
Objective. Study of initial levels of acute phase proteins in patients with pulmonary tuberculosis with and without relapse as predictors of unfavorable disease progression. Materials and methods. 2 groups of patients were examined: the base group - 55 patients with pulmonary tuberculosis with relapse and the control group - 55 patients with pulmonary tuberculosis without relapse. Acute phase protein content was studied in patients before and after the intensive phase of treatment. The content of complement factors C3 and C4, haptoglobin, ceruloplasmin, properdin, C-reactive protein, IL-6, VSH, leukocyte content was studied. Results. The obtained results reveal that acute phase proteins can be considered basic predictors of ineffective antituberculosis treatment: the high indices of leukocyte, C-reactive protein, IL-6, ESR, and haptoglobin.
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