THE EFFICIENCY OF IMMUNE MODULATOR BIVEL IN THE PREVENTION OF PULMONARY TUBERCULOSIS IN EXPOSED CHILDREN FROM THE MULTIDRUG-RESISTANT TUBERCULOSIS SITES
DOI:
https://doi.org/10.52692/1857-0011.2023.3-77.15Keywords:
BIVEL immunomodulator, pulmonary tuberculosis in children, cellular immunity, tuberculosisAbstract
120 exposed children/adolescents (75 children and 45 adolescents) from the multi-drug resistant tuberculosis sites underwent the complex clinical radiological and immunological examination.Insignificant functional disorders of cellular response (immunoregulatory processes) caused by the prevalence of suppressor and cytotoxic reactions by 1.3 times and by the prevalence of pro-inflammatory cytokines in the regulatory system (2.0 times above the norm, TNF-α/IL 10.0. р<0.01) were revealed in the infected children/adolescents from the multi-drug resistant tuberculosis sites, while their СD3+. СD3+СD4+. СD3+СD8+ were within norm. The evident disorders of the regulatory system and cell immune system were eliminated after the completion of the autumn-spring BI-V course. The non-specific immune regulator BI-V is efficient for the prevention of multi-drug resistant tuberculosis for the exposed children/adolescents from the multi-drug tuberculosis sites. Consequently, the latent TB infection grew into the active form by 2.8 times less often in the children that took BI-V as compared to the infected children who did not take the drug.
References
Abildaev T.Sh., Bekembaeva G.S., Kastykpaeva L.Z. The main risk factors of the disease in the foci of tuberculosis with drug resistance of the causative agent. Tuberculosis and lung diseases. 2014; 3: 33-35.
Aksenova V.A., Morozova T.Y. Tuberculosis in children of early age living in centers with drugresistant tuberculosis. Tuberculosis and lung diseases. 2015; 5: 26-27.
Aleksandrova E.N. , Morozova T.Y., Doctorova N.P. Defects in the prevention and detection of tuberculosis in children and adolescents at the outpatient stage. Tuberculosis and lung diseases. 2011; 1: 3-5.
Barbova A.I. Modern approaches to the diagnosis of multidrug-resistant tuberculosis. Ukrainian Pulmonology Journal. 2016; 2: 29-32.
Belogorseva O.I. Immunoprophylaxis of tuberculosis in children: problems and prospects. Ukrainian Pulmonology Journal. 2008; 3: Annex. 29-30.
Belogortseva O.I. Immunological and immunogenetic characteristics of children with different forms of tuberculosis. Ukrainian Pulmonology Journal. 1998; 1: 62-64.
Bilohortseva O.I. , Sukhanova L.A. , Shekhter I.Y. and others. Multidrug-resistant tuberculosis in Ukraine versus the general tuberculosis incidence. Ukrainian Pulmonology Journal. 2019; 1. Enclosure: 15-20.
Dotsenko Y.I., Belogogorseva O.I. Tuberculosis risk group in children with latent tuberculosis infection. Medical forum. 2016; 7: 61-63.
Melnyk V.M , MatusevichV.G. , Novozhilova I.O etc. Topical issues regarding chemoresistant tuberculosis in Ukraine. Ukrainian Pulmonology Journal. 2017; 2: 52.
Mykolyshyn L.I., Piskur Z.I., Didyk Y.Y., Sikirinska O.I. Clinical parameters of vitamin D in children’s tuberculosis. Modern pediatrics. 2016; No. 6 (78): 88-91.
Ovsyanka E.S., Panova L.V., Polektova F.A. and dr. Actual problems of tuberculosis in tenderness from tuberculosis tuberculosis. Tuberculosis and Lung Diseases. 2018; 96:6: 17-20. DOI: 10. 21292/20751230-2018-96-6-17-20.
Petrenko V.I. et al., Tuberculosis prevention: a textbook. Kyiv. LLC “Ridzhi”, 2017; 88 p.
Pyatnychka I.T., Kornaga S.I., Thorik N.V. Ways to reduce the spread of multidrug-resistant tuberculosis from the point of view of phthisioepidemiology. Herald of social hygiene and health care organization of Ukraine. 2014; 4 (62): 67-69.
Rekalova O.M., Belogortseva O.I, Koval N.G. Immunological methods of diagnosis of tuberculosis. Tuberculosis, lung diseases, HIV infection. 2017; 1(28). 75-83.
Sakhelashvili M.I., Kostyk O.P. , Platonova I.L. et al. Actual problems of multidrug-resistant tuberculosis and tuberculosis with extended resistance in the Lviv region. Ukrainian Pulmonology Journal. 2017; 2: 119-120.
Standards of medical care “Tuberculosis”. Order of the Ministry of Health of Ukraine dated January 19, 2023; 102: 79 p.
Feshchenko Yu.I. , Rekalova A.M. Features of modern immunomodulating therapy. Asthma and allergy. 2016; 2: 6-11.
Feshchenko Yu.I. , Melnyk V.M., Turchenko L.V. A look at the problem of fighting tuberculosis in Ukraine. Ukrainian Pulmonology Journal. 2016; 3: 5-10.
Daly R.M., Gagnon, Z.X. Lu et. al. Prevalence of vitamin D deficiency and its determinants in Australian adults aged 25 years and older: a national, populationbased study. Clinical Endocrinology (Oxf.). 2012; Vol. 77: 26-35.
Fares, A. Seasonality of tuberculosis. J. Global Infectious Diseases. 2011; Vol. 3: 46-55.
MacLachlan, J.H., Lavender C.J., Cowie B. C. Effect of Latitude on Seasonality of Tuberculosis, Australia, 2002-2011. Emerging Infectious Disease. 2012; Vol. 18: 1879-1881.
Parrinello C., Crossa A., Harris T. G. Seasonality of tuberculosis in New York City, 1990-2007. International J. of Tuberculosis and Lungs Disease. 2012; Vol. 16: 32-37.
Wingfield T., S.G. Schumacher, G. Sandhu et. al. The Seasonality of Tuberculosis, Sunlight, Vitamin D, and Household Crowding. J. of Infectious Disease. 2014; Vol. 210: 774-783.
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