Adverse hematological and coagulability reactions to the use of antituberculosis preparations


  • Nicolae BACINSCHI IP State University of Medicine and pharmacy " Nicolae Testemitanu”
  • Anna DONICA IMSP Institute of Phthisiopneumonology "Chiril Draganiuc"
  • Elena TUDOR IMSP Institute of Phthisiopneumonology "Chiril Draganiuc"



hematological adverse reactions, coagulability, antituberculosis preparations


Treatment of tuberculosis requires long-term use of antituberculosis drugs with a high risk of side effects. In recent decades, along with the frequent and detailed side effects (gastrointestinal symptoms, hepatotoxicity, neurotoxicity, allergic reactions), hematological and coagulation disorders have been described when taking antituberculosis drugs. Their main manifestations can be: iron deficiency anemia, hemolytic anemia, megaloblastic and sideroblastic anemia, thrombocytopenia, thrombocytopenic purpura, leukopenia, eosinophilia, agranulocytosis, deep vein thrombosis, thromboembolism, disseminated intravenous coagulopathy, etc. Although these side effects are rare, they require special attention because they can appear more frequently in the case of intermittent or interrupted treatment and present diagnostic difficulties.

Author Biographies

Nicolae BACINSCHI, IP State University of Medicine and pharmacy " Nicolae Testemitanu”

Doctor of Medical Sciences, Associate Professor, Researcher, Corresponding Member of the Academy of Sciences and Medicine;Department of Pharmacology and Clinical Pharmacology;

Anna DONICA, IMSP Institute of Phthisiopneumonology "Chiril Draganiuc"

Master of Medical Science and Public Health

Elena TUDOR, IMSP Institute of Phthisiopneumonology "Chiril Draganiuc"

Doctor of Medical Sciences, Associate Professor, Researcher, Corresponding Member of the Romanian Academy of Medical Sciences (AȘMM).


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Research Article