Interaction of antituberculosis drugs with food
DOI:
https://doi.org/10.52692/1857-0011.2023.3-77.38Keywords:
tuberculosis, antituberculosis drugs, interaction, foodAbstract
The peculiarities of the development and evolution of tuberculosis require a rich and varied diet to restore the nutritional status, reduce the incidence of gastrointestinal adverse reactions and increase adherence to treatment. Food can modify the pharmacokinetic parameters (Cmax, AUC, Tmax) and thus influence the effectiveness of antituberculosis drugs or contribute to the development of resistance. Rifampicin and isoniazid need to be taken on an empty stomach. Food does not significantly influence the pharmacokinetic parameters of pyrazinamide and ethambutol. Calcium-rich products will decrease the absorption of fluoroquinolones. Acidic drinks reduce the absorption and Cmax of cycloserine/terizidone and increase the absorption of paraaminosalicylic acid. Pharmacodynamic interaction can be observed when isoniazid is combined with products containing tyramine and histamine, with increased manifestations of adverse reactions.
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