Ovarian Brenner tumor


  • Ana MISHINA Institute of Mother and Child
  • Sergiu GLADUN Institute of Mother and Child
  • Lilia SINITSINA Institute of Mother and Child




Brenner tumor, ovary, treatment


The authors presents a clinical observation of a rare pathology - Brenner’s tumor of the ovary. A narrative review of the literature on the diagnosis and treatment of this pathology is given.

Author Biographies

Ana MISHINA, Institute of Mother and Child

Doctor of Medical Sciences; Surgical gynecology department

Sergiu GLADUN, Institute of Mother and Child

Doctor of Medical Sciences; Surgical gynecology department

Lilia SINITSINA, Institute of Mother and Child

Doctor of Medical Sciences; Morphopathology Department


Alloush F, Bahmad HF, Lutz B, Poppiti R, Recine M, Alghamdi S, Goldenberg LE. Brenner tumor of the ovary: A 10-year single institution experience and comprehensive review of the literature. Med Sci (Basel). 2023;11(1):18.

Pavlovic A, Glavina Durdov M, Lozic D, Skare Librenjak L, Alfirevic D. Primary ovarian lymphoma and benign Brenner tumor. Taiwan J Obstet Gynecol. 2016;55(1):138-9.

Lang SM, Mills AM, Cantrell LA. Malignant Brenner tumor of the ovary: Review and case report. Gynecol Oncol Rep. 2017;22:26-31.

Costeira FS, Félix A, Cunha TM. Brenner tumors. Br J Radiol. 2022;95(1130):20210687.

Abe T, Saida T, Fujieda K, Inoue K, Satoh T, Nakajima T. A case of Pseudo-Meigs’ syndrome due to Brenner tumor. Radiol Case Rep. 2023;18(3):1349-1352.

Zhao Y, Mao X, Yao L, Shen J. Computed tomography imaging features of benign ovarian Brenner tumors. Oncol Lett. 2018;16(1):1141-1146.

Yüksel D, Kılıç C, Çakır C, Kimyon Cömert G, Turan T, Ünlübilgin E, Boran N, Kayıkçıoğlu F, Koç S. Brenner tumors of the ovary: clinical features and outcomes in a single-center cohort. J Turk Ger Gynecol Assoc. 2022;23(1):22-27.

Zhang Y, Staley SA, Tucker K, Clark LH. Malignant Brenner tumor of the ovary: Case series and review of treatment strategies. Gynecol Oncol Rep. 2019;28:29-32.

Zheng R, Heller DS. Borderline Brenner tumor: A review of the literature. Arch Pathol Lab Med. 2019;143(10):1278-1280.

Montoriol PF, Hordonneau C, Boudinaud C, Molnar I, Abrial C, Kossai M. Benign Brenner tumour of the ovary: CT and MRI features. Clin Radiol. 2021;76(8):593-598.

Ricotta G, Maulard A, Genestie C, Pautier P, Leary A, Chargari C, Candiani M, Morice P, Gouy S. Brenner borderline ovarian tumor: A case series and literature review. Ann Surg Oncol. 2021;28(11):6714-6720.

Turgay B, Koyuncu K, Taşkın S, Ortaç UF. Features of ovarian Brenner tumors: Experience of a single tertiary center. Turk J Obstet Gynecol. 2017;14(2):133-137.

Weinberger V, Minář L, Felsinger M, Ovesná P, Bednaříková M, Číhalová M, Jandáková E, Hausnerová J, Chaloupková B, Zikán M. Brenner tumor of the ovary ultrasound features and clinical management of a rare ovarian tumor mimicking ovarian cancer. Ginekol Pol. 2018;89(7):357-363.

Falkins AK, Palacios J, Xue WC. Female genital tumours. WHO classification of tumours. 5th ed. IARC Press; Lyon: 2020. Tomours of the ovary; Brenner tumour; pp. 71–72.

Garofalo G, Bucella D, Thomas D, Buxant F. Fertility-sparing surgery for borderline ovarian Brenner tumor and subsequent childbirth: First case report and a literature review. Clin Case Rep. 2022;10(12):e6609.

Heimbigner AM, Davaro EP, Schwetye K. Benign brenner tumor in an ectopic ovary: A case report and review of literature. Int J Gynecol Pathol. 2021;40(4):376-378.

Abbas AM, Amin MT. Brenner’s tumor associated with ovarian mucinous cystadenoma reaching a huge size in postmenopausal woman. J Cancer Res Ther. 2015;11(4):1030.

Maghbool M, Samizadeh B. Mixed mucinous cystadenoma with benign Brenner tumor in a huge ovarian mass, a case report and review of literature. Int J Surg Case Rep. 2022;92:106859.

Sah S, McCluggage WG. Ovarian combined Brenner tumor, mucinous cystadenoma and struma ovarii: First report of a rare combination. Int J Gynecol Pathol. 2019;38(6):576-580.

Gaur JH, Hassan MJ, Elahi AA, Khetrapal S, Khan S, Jetley S. Synchronous benign Brenner’s tumor of ovary with leiomyoma and endometrial adenocarcinoma in a postmenopausal female. J Cancer Res Ther. 2019;15(6):1418-1420.





Research Article