Drug – related cardiac problems

Аннотация

More than 10% of patient receiving the drug have been found to have evidence of digoxin toxicity when admitted to hospital. Digoxin toxicity can cause any arrhythmia, and various conduction disturbance. For life-threatening arrhythmias, digoxin specifi c antibodies (Digibind) are the treatment of choice. Tricyclic antidepressants (TCADs) result in significant mortality when taken in overdose duet o the cardiovascular effects of hypotension, myocardial depression and arrhythmias. The anticholinergic effects may delay gastric emptying, and a large, single dose of activated charcoal administration should be considered, particularly if ingestion has occurred within an hour of presentation. Any hypoxia and electrolyte or metabolic disturbances should be corrected. Seizures should be treated with diazepam, as other anticonvulsant agents. Recreational drugs are complex and can induce profound changes in cardiovascular function, both acutely and chronically. Recreational drugs are often taken together, which can result in complex synergistic interactions with potentially detrimental effects. A high index of suspicion with early intervention and management is often the key to successful treatment.