Polymorphism N34S of the spink1 gene in ukrainian patients with different forms of acute pancreatitis

Аннотация

Background and Aims: We have studied polymorphism N34S of the SPINK1 gene in patients with different forms of acute pancreatitis, living in the Chernivtsi region of Ukraine. Materials and Methods: The material of the research consisted of 37 persons with different forms of acute pancreatitis. The patients were subdivided into 2 groups. The first group consisted of 17 patients with acute edematous pancreatitis. The second group included 20 patients with pancreatonecrosis. All the patients underwent a complex laboratory - instrumental examination in accordance with the protocol of providing medical care to patients with acute pancreatitis. In addition, a genetic analysis was performed in all the persons for the purpose of studying polymorphism N34S of SPINK1 gene. Results: In has been established that among patients with different forms of acute pancreatitis the carriage of the favorable N-allele is more common (45.9% and 51.4%), with a lower number of abnormal SS-homozygotes (2.7%). The incidence of the onset of the biliary form of acute pancreatitis is not associated with a certain genotype of the N34S polymorphism of the SPINK1 gene. The nonbiliary form of acute pancreatitis is insignificantly more common in carriers of the mutant S-allele: 29.7% (11) versus 18.9% (7) persons. Conclusion: The carriage of the unfavorable SS-genotype is a probable predisposing factor of a disease initiation and a potentiation of its further progression.