Evaluation of consumption in DDD of other beta-lactam antibacterials use in hospitals

Abstract

Other beta-lactam antibacterials remain as the most consumption antibiotics in hospitals with the rate around 50% from all of them. The strategic action plan on antibiotic resistance with the slogan “No action today, no cure tomorrow” was marketed at the World Health Organization Day in 2011. From this event start a number of key strategic actions that proposed to mitigate, prevent and control antibiotic consumption and resistance. These include promoting the prudent use of antibiotics across many sectors; strengthening surveillance systems to monitor the use of antibiotics and resistant bacteria and others. Our aim was to evaluate institutional representative data on other beta-lactam antibacterials utilization for a period of six years (2009-2014), according to WHO requirements to determine value of defi ned daily doses (DDD) per 1000 occupied occupied-bed days (OBD). The cephalosporin’s G-I decrease considerably consumption form 192.2 to 96.8 DDD/1000 or by 50% and conversely cephalosporin’s G-II and G-III recorded an increase from 78 (16.1 61.9) to 173.9 (49.4 124.5) DDD / 1000 or 2.3 times. A big change was observed in ratio of DDD/1000 used for parenteral and respectively oral forms from 268.5 (99.1%) and 2.2 (0.9%) in 2009 to 247.3 (90.7%) and 25.3 (9.3%) in 2014