Evolution of the destructive tuberculosis in children

Authors

  • Evelina LESNIC Department of pneumophthisiology, IP State University of Medicine and pharmacy “Nicolae Testemitanu", Republic Of Moldova
  • Adriana NIGULEANU Department of pneumophthisiology, IP State University of Medicine and pharmacy “Nicolae Testemitanu", Republic Of Moldova

DOI:

https://doi.org/10.52692/1857-0011.2021.3-71.12

Keywords:

tuberculosis, treatment, outcome

Abstract

The aim of the study was to evaluate the outcome of pulmonary tuberculosis with lung destruction in children.Material and methods: a retrospective, selective, analytical research was performed, which included 43 children withtuberculosis. Results: the most frequently affected were girls 25 (58.1%) and the age group between 15 and 18 years 34(79.1%) cases.. Every second child was in tuberculous contact, 41.9% were actively detected and passively 22 (52.4%)cases, even if all patients were symptomatic. Infiltrative tuberculosis predominated, in equally proportion was extendedand limited, in most patients with unilateral localization, and with dissemination. Microscopic positive were 20 (46.5%)cases, GeneXpert MTB / Rif positive 30 (69.8%) cases, including resistant in 9 (20.9%) cases. Therapeutic success wasregistered in 30 (69.8%) cases, 2 (4.7%) cases were lost to follow-up, continued treatment with TB RR/MDR 11 (25.6%)children. Conclusions: destructive pulmonary tuberculosis evolves with unsatisfactory therapeutic results, due to theassociation with epidemiological risk factors, passive detection, extensive localization and bronchogenic dissemination.

Author Biographies

Evelina LESNIC, Department of pneumophthisiology, IP State University of Medicine and pharmacy “Nicolae Testemitanu", Republic Of Moldova

dr.șt.med.

Adriana NIGULEANU, Department of pneumophthisiology, IP State University of Medicine and pharmacy “Nicolae Testemitanu", Republic Of Moldova

dr.șt.med

References

World Health Organization. Tuberculosis Report, 2020. https://www.who.int/publications/i/item/9789240013131

Centrul Național de Management în Sănătate. Notă informativă privind situația epidemiologică a tuberculozei, Chișinău, 2020. Valabil: https://simetb.ifp.md/Download/tbreps.excel/raport_2020

Iavorschi C., Paladi C, Niguleanu A., Lesnic E., Marcoci L, Cebotari C, Ceban R. Factori de risc ai adolescenților bolnavi de tuberculoză. În: Buletinul Academiei de Ştiinţe a Moldovei. Chisinau, 2016, nr. 1, p. 70-74. ISSN 1857-0011.

Iavorschi C., Paladi C, Lesnic E., Niguleanu A., Bivol L. Considerații clinic-radiologice și microbiologice ale tuberculozei la adolescenți. În: Buletinul Academiei de Ştiinţe a Moldovei. Chisinau, 2016, nr. 1, p. 74-77. ISSN 1857-0011.

Protocol Clinic Național. Tuberculoza la Copil. Chișinău, 2020, 180 p. Valabil pe https://msmps.gov.md/wp-content/uploads/2021/02/PCN-55-Tuberculoza_la_copil.pdf

Published

2021-11-17

Issue

Section

Research Article