LIPID SPECTRUM IN PATIENTS WITH PULMONARY TUBERCULOSIS

Authors

  • Dmitriy Sergeevich RYASENSKIY Tver State Medical University of the Ministry of Health of the Russian Federation, Department of Phthisiology, 170100, Tver, Russia
  • Alexander Vladimirovich ASEEV Tver State Medical University of the Ministry of Health of the Russian Federation, Department of Phthisiology, 170100, Tver, Russia
  • Akhmed Ibragimovich ELGALI Tver State Medical University of the Ministry of Health of the Russian Federation, Department of Phthisiology, 170100, Tver, Russia

DOI:

https://doi.org/10.52692/1857-0011.2021.3-71.15

Keywords:

Lipid spectrum of the blood plasma, immunocytes, pulmonary tuberculosis

Abstract

The evaluation of the lipid spectrum of the blood plasma and immunocyte membranes is important for timely diagnosticand correction of pathological changes revealed at the cytochemical level. The identification of lipid fractions using high-performance liquid chromatography (HPLC) allows for separate detection of minor fractions of lysophospholipids (lysophosphatidylcholine and lysophosphatidylethanolamine). The study was performed using a photometric sensor and reverse-phasecolumn C18. The following fractions were obtained: lysophosphatidylcholine, lysophosphatidylethanolamine, sphingomyelin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, and phosphatidylserine. The ratio of these fractionsis a sensitive marker of pathological shifts in the lipid spectrum both in the blood plasma and immunocyte membranes.Keywords: Lipid spectrum of the blood plasma, immunocytes, pulmonary tuberculosis.

Author Biographies

Dmitriy Sergeevich RYASENSKIY, Tver State Medical University of the Ministry of Health of the Russian Federation, Department of Phthisiology, 170100, Tver, Russia

Candidate of Medical Sciences, Associate Professor

Alexander Vladimirovich ASEEV, Tver State Medical University of the Ministry of Health of the Russian Federation, Department of Phthisiology, 170100, Tver, Russia

Doctor of Medical Sciences, Head of the Department

Akhmed Ibragimovich ELGALI, Tver State Medical University of the Ministry of Health of the Russian Federation, Department of Phthisiology, 170100, Tver, Russia

Assistant at the Departmen

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Published

2021-11-17

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Research Article