INFLUENCE OF COMPENSATION OF SELENIUM DEFICIENCY ON IMMUNOLOGICAL PARAMETERS OF PATIENTS WITH MULTIDRUG-RESISTANT TUBERCULOSIS AT THE BACKGROUND OF SUBCLINICAL HYPOTHYROIDISM
DOI:
https://doi.org/10.52692/1857-0011.2021.3-71.20Keywords:
multidrug-resistant tuberculosis, thyroid gland, sodium selenite, chemotherapyAbstract
In 60 patients with multidrug-resistant tuberculosis at the background of subclinical hypothyroidism serum level ofselenium, thyroid state and immunological parameters were studied in dynamic of the intensive phase of chemotherapy.Initially low level of selenium, subclinical hypothyroidism and weaken immunological response toward tuberculosis werediagnosed. Prescribing of selenite sodium with 200 µ daily during 60 daily doses normalized serum level of selenium,restored thyroid function and improved immunological response. Using of selenite sodium like an accompanying medicine during chemotherapy of multidrug tuberculosis at the background of subclinical hypothyroidism after estimation ofserum level of selenium is recommended.
References
Avery J.C., Hoffman P.R. Selenium, selenoproteins and immunity. Nutriens, 2018; 10(9): 1203-14
Csaba G., Pallinger E. Thyrotropic hormone (TSH) regulation of triidthyronine (T3) concentration in immune cells. Inflamm. Res., 2009; 58: 151-4
Davis S.L. Environmental modulation of the immune system via the endocrine system. Domest. Anim. Endocrinol., 1998.15: 283-9
Dorshkind K., Horseman N.D. The roles of prolactin, growth factor-I, and thyroid hormones in lymphocyte development and function: insights from genetic models of hormone and hormone receptor deficiency. Endocrine. Rev., 2000; 21: 292-312
Duntas L.H. Selenium and the thyroid: a close knit connection. Journal of Clin Endoxinol & Metabol, 2010; 95 (12):5180-8
Drutel A. Selenium and thyroid gland: more good news for clinicians. Clin Endocrinol (Oxf), 2013; 78 (2): 155-64
Foster M.P., Jensen E.R., Montecino-Rjdriguez E., Leathers H., Horseman N., Dorshkind K. Humoral and cell madiated immunity in mice with genetic deficiencies of prolactin, growth hormone, insulin-like growth factor-I, and thyroid hormones. Clin. Immunol., 2000; 96: 140-9
Frick L.R., Rapanelli M., Bussman U.A, Kleche A.J. et al. Involvement of thyroid hormones in the alterations of T-cell immunity and tumor progression. Biol. Psychiatry, 2009: 65 (11): 935-42
Hodkinson C.F., Simpson E.E.A., Beattie J.H., O’Connor J.M., Campbell D.J., Strain J.J., Wallace J.M. Preliminary evidence of immune function modulation by thyroid hormones in healthy men and women aged 55–70 years. J. Endocrinol., 2009; 202; 55-63
Kleche A.J. et al. Involvement of thyroid hormones in the alterations of T-cell immunity and tumor progression. Biol. Psychiatry, 2009; 65 (11): 935-42
Kohler S., Senn O., Saler L. et al Timing of Thyroxine Adjustment in Hypothyroid Patient: When are TSH Levels Stable. Journal of Thyroid Disorders and Therapy, 2011; 3: 31-35
Mahuad C., Bozza V., Pezzotto SM, Bay ML, Besedovsky H., del Rey A, Botasso O. Impaired immune responses in tuberculosis patients are related to weight loss that coexists with immunoendocrine imbalance. Clin. Exp. Immunol., 2007; 14 (3-4): 193-9
Matvyeyeva S.L., Shevchenko O.S., Pogorelova O.O. The function of thyroid gland in patients with multi-drug resistant tuberculosis. Antimicrobial Resistance & Infection Control, 2017; 82(6): 2279-85
Stuss M., Michalska-Kasiczak M., Sewerynek E. The role of selenium in thyroid gland pathphysiology. Endokrynol. Pol., 2017; 68 (4): 440-54
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