Clinical dilemmas: beta-adrenoblockers in atherosclerosis


  • Liuba POPESCU IMSP Institutul de Cardiologie; Clinica “Hipertensiuni Arteriale”
  • Alexandru CARAUȘ IMSP Institutul de Cardiologie; Clinica “Hipertensiuni Arteriale”
  • Anna MOISEEVA IMSP Institutul de Cardiologie; Clinica “Hipertensiuni Arteriale”
  • Ana COTELEA IMSP Institutul de Cardiologie; Clinica “Hipertensiuni Arteriale”



beta-adrenoblockers, atherosclerosis


Beta-blockers are the cornerstone of treatment for various cardiovascular conditions. Beta-blockers were discovered as antianginal drugs in the 1960s and are currently widely used in heart failure, arrhythmias, and ischemic heart disease. In this article, we review the evidence for the beneficial effects of beta-blockers in these conditions, as well as the current recommendations in clinical practice guidelines for their use. Surprisingly, despite having been prescribed for more than 4 decades, new, previously unnoticed mechanisms of action on cellular compartments are still being discovered, which continues to open up new horizons for their use. All in all, beta-blockers are one of the most fascinating drug groups in our therapeutic armamentarium.

Author Biographies

Liuba POPESCU, IMSP Institutul de Cardiologie; Clinica “Hipertensiuni Arteriale”

dr. șt. med., conferențiar cercetător

Alexandru CARAUȘ, IMSP Institutul de Cardiologie; Clinica “Hipertensiuni Arteriale”

dr. h. st. med., profesor cercetător

Anna MOISEEVA, IMSP Institutul de Cardiologie; Clinica “Hipertensiuni Arteriale”

dr. șt. med, cercetător științific

Ana COTELEA, IMSP Institutul de Cardiologie; Clinica “Hipertensiuni Arteriale”

cercetător științific.


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Research Article