Clinical forms, detection and diagnosis of tuberculosis in children during the pandemic and postpandemic period of COVID-19

Authors

  • Stela KULCITKAIA State University of Medicine and Pharmacy "Nicolae Testemițanu"
  • Constantin IAVORSCHI State University of Medicine and Pharmacy "Nicolae Testemițanu"; IMSP Institutul de Pneumologie "Chiril Draganiuc"
  • Elena TUDOR IMSP Institutul de Ftiziopneumologie “Chiril Draganiuc”
  • Lilia CHIOSEA Public Medical-Sanitary Institution Municipal Clinical Children's Hospital "V. Ignatenco"
  • Alina TOMSHA Public Medical-Sanitary Institution Municipal Clinical Hospital of Phthisiopneumology

DOI:

https://doi.org/10.52692/1857-0011.2024.2-79.11

Keywords:

tuberculosis, COVID-19, children, diagnosis, pandemic

Abstract

Clinical forms, detection and diagnosis of tuberculosis in children during the pandemic and post-pandemic period of COVID-19. Introduction. The pandemic caused by COVID-19 has had a major impact on tuberculosis (TB) screening. WHO declared in a. 2022 an 18% decrease in notified TB cases between 2019 and 2020 - from 7.1 to 5.8 million cases and a 20% increase in TB deaths over the next 5 years as a result of the COVID-19 pandemic. The aim of the study. Assessment of the impact of the COVID-19 pandemic on the detection, diagnosis and evolution of TB in children. Material and methods. A retrospective study was carried out which included the analysis of 610 cases of patients aged between 0-18 years, admitted for treatment in the Municipal Clinical Hospital Chisinau between 2019 and 2023. Results. TB predominated in the 0-9 age group. The diagnosis of intrathoracic lymph node TB was established in 68% of cases. Complications were more common in 2023. Conclusion. During the COVID-19 pandemic, a faulty detection of TB is attested.

Author Biographies

Stela KULCITKAIA , State University of Medicine and Pharmacy "Nicolae Testemițanu"

Doctor of Medical Sciences, University Associate Professor

Constantin IAVORSCHI, State University of Medicine and Pharmacy "Nicolae Testemițanu"; IMSP Institutul de Pneumologie "Chiril Draganiuc"

Dr. hab. med. sci., res. prof., acad. ASM

Elena TUDOR, IMSP Institutul de Ftiziopneumologie “Chiril Draganiuc”

Dr. med. sci., research assoc. prof., corr. member of ASM

Lilia CHIOSEA, Public Medical-Sanitary Institution Municipal Clinical Children's Hospital "V. Ignatenco"

M.M.S.P., pediatric pulmonologist

Alina TOMSHA, Public Medical-Sanitary Institution Municipal Clinical Hospital of Phthisiopneumology

phthisiopediatrician

References

Tuberculoza la copil. Protocol Clinic National. PCN-55. Chișinău, 2023. 217 p.

Migliori GB, Thong PM, Akkerman O, Alffenaar JW et al. Worldwide Effects of Coronavirus Disease Pandemic on Tuberculosis Services. January-April 2020. J Emerg Infect Dis. 2020 Nov;26(11):2709-2712. https://doi.org/10.3201/eid2611.203163.

Migliori GB, Thong PM, Alffenaar JW, Denholm Jet al. Country-specific lockdown measures in response to the COVID-19 pandemic and its impact on tuberculosis control: a global study. J Bras Pneumol. 2022;48(2): e20220087.

Migliori GB, Thong PM, Alffenaar JW, Denholm Jet al. Global Tuberculosis Network. Gauging the impact of the COVID-19 pandemic on tuberculosis services: a global study. Eur Respir J. 2021 Nov 11;58(5):2101786.

McQuaid CF, Vassall A, Cohen T, Fiekert K, White RG. The impact of COVID-19 on TB: a review of the data. Int J Tuberc Lung Dis. 2021 Jun 1;25(6):436-446.

Rodrigues I, Aguiar A, Migliori GB, Duarte R. Impact of the COVID-19 pandemic on tuberculosis services. Pulmonology. 2022 May-Jun;28(3):210-219.

Shah I, Gupta Y. Role of molecular tests for diagnosis of tuberculosis in children. Pediatric Oncall Journal. 2015;12(1)

Silva DR, Mello FCQ, D’Ambrosio L, Centis R, Dalcolmo MP, Migliori GB. Tuberculosis and COVID-19, the new cursed duet: what differs between Brazil and Europe? J Bras Pneumol. 2021 Apr 30;47(2):e20210044.

Systematic screening for active tuberculosis. Principles and recommendations. Geneva: World Health Organization; 2013 (WHO/HTM/TB/2013.04).

The End TB Strategy. Global strategy and targets for tuberculosis prevention, care and control after 2015. Geneva, Switzerland. https://www.aidsdatahub.org/sites/default/files/resource/end-tb-strategy-2015.pdf

Tadolini M, Codecasa LR, García-García JM, Blanc FX, Borisov S et. Active tuberculosis, sequelae and COVID-19 co-infection: first cohort of 49 cases. Eur Respir J. 2020 Jul 9;56(1):2001398.

WHO consolidated guidelines on tuberculosis. Module 1: prevention – tuberculosis preventive treatment. Geneva: World Health Organization; 2020. https://www.who.int/publications/i/item/9789240002906.

WHO consolidated guidelines on tuberculosis Module 2: Screening – Systematic screening for tuberculosis disease. Geneva: World Health Organization; 2021. https://www.who.int/publications/i/item/9789240022676

World Health Organization. Global tuberculosis report 2022: Geneva, Switzerland, 2021. https://apps.who.int/iris/handle/10665/340256

World Health Organization. Global tuberculosis report 2023: Geneva, Switzerland, 2024. https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2024/

Gupta U, Prakash A, Sachdeva S, Pangtey GS, Khosla A, Aggarwal R, et al. COVID-19 and Tuberculosis: A Meeting of Two Pandemics! J Assoc Physicians India. 2020;68(12):69-72.

Programul Naţional de Răspuns la Tuberculoză pentru anii 2022–2025. https://www.legis.md/cautare/getResults?doc_id=130171&lang=ro

Published

2025-04-18

Issue

Section

Research Article

Categories