DYNAMICS OF FIBROSIS MARKERS ON THE BACKGROUND OF TB/HIV CO-INFECTION TREATMENT
DOI:
https://doi.org/10.52692/1857-0011.2024.2-79.18Keywords:
tuberculosis, HIV infection, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, oxyprolineAbstract
TB/HIV co - infection remains one of the biggest medical problems in Ukraine and the world. In tuberculosis, MTB stimulates immunocompetent cells to produce MMP-9, which destroys collagen fibers. The inhibitor of MMP-9 is TIMP- 1, and the product of destruction of collagen fibers is oxyproline. In HIV/TB co - infection, the immune response is altered. Therefore, we performed a study of the levels of MMP-9, TIMP-1 and oxyproline in patients with MDR-TB with HIV co -infection. The comparison group included TB patients without HIV. Our research revealed that the level of MMP-9 in patients with MDR-TB remained stable during the study. In patients with HIV/TB co - infection, there is a violation of the regulation of the balance of MMP-9 and TIMP-1, which affects the processes of fibrosis and causes a severe disease course.
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