Immunological and allergic reactivity in children with toxocariasis and respiratory conditions: the effect of combined treatment
DOI:
https://doi.org/10.52692/1857-0011.2024.2-79.19Keywords:
toxocariasis, immune response, therapeutic approaches, childrenAbstract
Toxocariasis, a helminthic disease caused by Toxocara canis and Toxocara cati, primarily affects children, who are more susceptible to infection due to exposure to contaminated environments. The study included 50 children, with diagnosis confirmed through ELISA testing, and the treatments used were Albendazole, both in monotherapy and in combination with Proteflazid. The results showed a significant reduction in respiratory symptoms, levels of eosinophils, and specific antibodies after treatment, with more pronounced effects in the group receiving the combined treatment. The conclusions of the study suggest that combined therapeutic approaches may optimize the management of toxocariasis in children, thereby improving the immunological response.
References
Chieffi P.P., Zevallos Lescano S.A., Rodrigues E., Fonseca G., Vieira dos Santos S. Human toxocariasis: 2010 to 2020. Contributions from Brazilian Researchers. Research and Reports in Tropical Medicine, 2021; 12:81-91.
Chen J., Liu Q., Liu G.H., Zheng W.B., Hong S.J., Sugiyama H., Zhu X.Q., Elsheikha H.M. Toxocariasis: a silent threat with a progressive public health impact. Infect Dis Poverty, 2018; 7(1): p. 59.
Fillaux J., Magnaval J-F. Laboratory diagnosis of human toxocariasis. Vet Parasitol., 2013; 193(4):327-36.
Hombu A., Yoshida A., Kikuchi T., Nagayasu E., Kuroki M., Maruyama H. Treatment of larva migrans syndrome with long-term administration of Albendazole. J. Microbiol. Immunol. Infect., 2019; 52:100-5.
Placinta Gh. Monoinvasion with Toxocara canis in children. The Moldovan medical Journal, 2018,; 61(2):17-20.
Rostami A., Riahi S.M., Holland C.V., Taghipour A., et al. Seroprevalence estimates for toxocariasis in people worldwide: A systematic review and meta-analysis. PLOS Negl Trop Dis., 2019; 13(12):e0007809.
Rotaru-Lungu C. Caracteristica clinico – imunologică a toxocarozei asociată cu maladii respiratorii la copii. Autoreferatul tezei de doctor în ştiinţe medicale. Chișinău, 2024, 194 p.
Șciuca S., Ghinda S., Gudumac V., Tomacinschii C. Sistemul imun și metode de diagnostic în imunologie. Recomandare metodică. Chișinău, 2018, 74 p.
Wiśniewska-Ligier M., Woźniakowska-Gęsicka T., Sobolewska-Dryjańska J. et al. Analysis of the course and treatment of toxocariasis in children-a long-term observation. Parasitol Res., 2012; 110:2363–71.
Гилмуллина Ф. С. Клинико-эпидемиологические особенности, диагностика и лечение токсокароза у детей. Практическая медицина, 2019; 8(17):58- 61.
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