The features of tuberculosis with multiple locations

Authors

  • Adriana NIGULEANU Nicolae Testemițanu State University of Medicine and Pharmacy
  • Cristina GUMENIUC Nicolae Testemițanu State University of Medicine and Pharmacy
  • Alina MALIC Nicolae Testemițanu State University of Medicine and Pharmacy
  • Tatiana OSIPOV Nicolae Testemițanu State University of Medicine and Pharmacy
  • Evelina LESNIC Medical Clinic "Analitic Med"
  • Raisa CEBAN Municipal Clinical Hospital of Phthisiopneumology
  • Constantin IAVORSCHI PMSI Institute of Pneumology "Chiril Draganiuc"
  • Albina BRUMARU PMSI Institute of Pneumology "Chiril Draganiuc"
  • Lidia RIVNEAC PMSI Institute of Pneumology "Chiril Draganiuc"
  • Elena TUDOR PMSI Institute of Pneumology "Chiril Draganiuc"

DOI:

https://doi.org/10.52692/1857-0011.2024.2-79.37

Keywords:

disseminated TB, TB with multiple locations, diagnosis

Abstract

Tuberculosis (TB) with multiple locations (TBML) is a severe form of TB, with a high mortality rate, particularly in the population with recognized risk factors, including HIV infection and immunodeficiencies of any origin. Aim was to analyze the data from existing sources of literature regarding TBML. The scientific publications from PubMed and Elsevier databases were studied. Review presented included data on the recent epidemiological situation, concepts of pathogenesis mechanisms, clinical picture, imaging features, laboratory test results and treatment principles of patients with TBML. The diagnosis of TBML relies on a multidirectional approach that requires clinical suspicion and confirmation by complex analyses, especially bacteriological and histological examinations.

Author Biographies

Adriana NIGULEANU, Nicolae Testemițanu State University of Medicine and Pharmacy

Doctor of Medical Sciences, University Assistant

Cristina GUMENIUC, Nicolae Testemițanu State University of Medicine and Pharmacy

medical resident

Alina MALIC, Nicolae Testemițanu State University of Medicine and Pharmacy

Doctor of Medical Sciences, Associate Professor

Tatiana OSIPOV, Nicolae Testemițanu State University of Medicine and Pharmacy

University Assistant

Evelina LESNIC , Medical Clinic "Analitic Med"

Doctor of Medical Sciences

Raisa CEBAN , Municipal Clinical Hospital of Phthisiopneumology

phthisiopulmonologist

Constantin IAVORSCHI, PMSI Institute of Pneumology "Chiril Draganiuc"

Habilitated Doctor of Medical Sciences, Research Professor, Academician of the Academy of Sciences of Moldova

Albina BRUMARU, PMSI Institute of Pneumology "Chiril Draganiuc"

Doctor of Medical Sciences, Senior Researcher

Lidia RIVNEAC , PMSI Institute of Pneumology "Chiril Draganiuc"

Doctor of Medical Sciences, Senior Researcher

Elena TUDOR, PMSI Institute of Pneumology "Chiril Draganiuc"

Doctor of Medical Sciences, Senior Researcher, Corresponding Member of the Academy of Sciences of Moldova

References

Cadena A.M., Fortune S.M., Flynn J.L. Heterogeneity in tuberculosis. Nat. Rev. Immunol., 2017; 17(11):691-702.

Chung E.S., Johnson W.C., Aldridge B.B. Types and functions of heterogeneity in mycobacteria. Nat. Rev. Microbiol., 2022; 20(9):529-541.

Hang T.-X., Fang G., Huang Y., Hu C.-M., Chen W. Misdiagnosis of a multi-organ involvement hematogenous disseminated tuberculosis as metastasis: a case report and literature review. Infec. Dis. of Poverty, 2020; 9(1):66.

Heffernan C., Rowe B.H., Long R. Engaging frontline providers: an important key to eliminating tuberculosis in Canada, and other high-income countries. Can. J. Public Health, 2021; 112(5):872-876.

Hu M.A. Case of Multi-Organ Tuberculosis Misdiagnosed as Lung Cancer and a Literature Review. Cancer Manag. Res., 2023; 15:1395-1400.

Hunter R.L. The pathogenesis of tuberculosis–the Koch phenomenon reinstated. Pathogens, 2020; 9(10):813.

Khan F.Y. Review of literature on disseminated tuberculosis with emphasis on the focused diagnostic workup. J. Family Community Med., 2019; 26(2):83-91.

Khan F.Y., Dosa K., Fuad A., et al. Disseminated tuberculosis among adult patients admitted to Hamad general hospital, Qatar: A five year hospital based study. Mycobact. Dis., 2016; 6(212):2161-1068.

Khan F.Y.A. Peritoneal tuberculosis: Advances and controversies. Libyan J. of Med. Sciences, 2018; 2(1):3-7.

Long R., Asadi L., Heffernan C., et al. Is there a fundamental flaw in Canada’s post-arrival immigrant surveillance system for tuberculosis? PLoS One, 2019; 14(3): e0212706.

Long R., Divangahi M., Schwartzman K. Chapter 2: Transmission and pathogenesis of tuberculosis. Can. J. of Res. Crit. Care, and Sleep Med., 2022; 6(sup1): 22-32.

Lynn S.Z. The World Health Organization Recommended TB Diagnostic Tools. Tuberculosis, 2018; 2:1-90.

Martini K., Loubet A., Bankier A., et al. Nodular reverse halo sign in active pulmonary tuberculosis: A rare CT feature? Diagn. Interv. Imaging., 2020; 101(5): 281-287.

Menzies D. Canadian Tuberculosis Standards 8th edition: What’s new? And what’s next? Can. J. of Res., Crit. Care, and Sleep Med., 2020; 6(6):333-336.

Menzies, N.A., Wolf,E., Connors D., et al. Progression from latent infection to active disease in dynamic tuberculosis transmission models: a systematic review of the validity of modelling assumptions. The Lancet Infec. Dis., 2018; 18(8): e228-e238.

Ribeiro S., Trabulo D., Cardoso C., еt al. Disseminated Tuberculosis in an Immunocompetent Patient: The Answer is in the Liver. GE - Portuguese J. of Gastroenterol., 2016; 23(4): 208-213.

Rolo M., González-Blanco B., Reyes C.A., et al. Epidemiology and factors associated with Extra- pulmonary tuberculosis in a Low-prevalence area. J. Clin. Tuberc. Other Mycobact. Dis., 2023; 32: 100377.

Sharma S.K., Mohan A. Miliary Tuberculosis. Microbiol. Spectr., 2017; 5(2) [online].

Shaw J.A., Diacon A.H., Koegelenberg C.F. Tuberculous pleural effusion. Respirology, 2019; 24(10): 962-971.

Tobin E.H., Tristram D. Tuberculosis. [Updated 2024 Aug 11]. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024. https://www.ncbi.nlm.nih.gov/books/NBK441916/

Vohra S., Dhaliwal H.S. Miliary Tuberculosis. [Updated 2024 Jan 30]. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK562300/

Zhan Y., Li B., Huo Y., et al. A case of multiple organ tuberculosis. Radiology of Infec. Dis., 2018; 5(1): 50-54.

World Healph Organization. Global tuberculosis report 2023: WHO. 2023.

Published

2025-04-18

Issue

Section

Research Article

Categories