Suspected autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) - clinical case
DOI:
https://doi.org/10.52692/1857-0011.2024.3-80.37Keywords:
PANDAS, PANS, autoimmune reaction, streptococcus, ticsAbstract
The autoimmune neuropsychiatric disorder associated with streptococcal infection (PANS/PANDAS) is a rare subtype of idiopathic autoimmune encephalitis that manifests as recently developed tics and obsessive - compulsive disorder following an infection with Group A beta - hemolytic Streptococcus. This clinical case illustrates a rare situation of suspected PANDAS and highlights the need for national management protocols for autoimmune neurological pathologies.
References
Hardin H, Shao W, Bernstein JA. An updated review of pediatric autoimmune neuropsychiatric disorders associated with Streptococcus/pediatric acute-onset neuropsychiatric syndrome, also known as idiopathic autoimmune encephalitis: What the allergist should know. Ann Allergy, Asthma Immunol. 2023;131(5):567–75.
La Bella S, Scorrano G, Rinaldi M, et al. Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS): Myth or Reality? The State of the Art on a Controversial Disease. Microorganisms. 2023;11(10).
Swedo SE, Leonard HL, Garvey M, et al. Associated With Streptococcal Infections : Clinical Description of the First 50 Cases. Am J Psychiatry. 1998;155:2(February):264–71.
Maini B, Bathla M, Dhanjal GS, Sharma PD. Pediatric autoimmune neuropsychiatric disorders
Leonardi L, Perna C, Bernabei I, et al. Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS): Immunological Features Underpinning Controversial Entities. Children. 2024;11(9):1043.
Bottoms N, Rice S, Veerapandiyan A. Editorial: Pediatric autoimmune neuropsychiatric syndrome. Front Behav Neurosci. 2024;18.
Consensus statement on childhood neuropsychiatric presentations , with a focus on PANDAS / PANS. Br Paediatr Neurol Assoc. 2023;(April).
Frankovich J, Swedo SE, Murphy T, et al. Clinical Management of Pediatric Acute-Onset Neuropsychiatric Syndrome : Part II - Use of Immunomedulatory Therapies. J Child Adolesc Psychopahrmacology. 2017;27(7):574–93.
Sivakanthan A, Gedeon J, Sadaf S, Bodic M. Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections Manifestations in a Teenager. Prim Care Companion CNS Disord. 2023;25(5).
Pavone P, Cacciaguerra G, Sapuppo A, et al. PANS / PANDAS : Clinical Experience in IVIG Treatment and State of the Art in Rehabilitation Approaches Psychiatric manifestations Tics phenotypes. Neurosciences. 2020;55(1):75–84.
Downloads
Published
License
Copyright (c) 2025 Bulletin of the Academy of Sciences of Moldova. Medical Sciences

This work is licensed under a Creative Commons Attribution 4.0 International License.