Applicability of modern biotechnologies and phytotherapeutic products in integrative oncological medicine: from the lab bench to the patient’s bedside

Abstract

The paper justifies its theme by highlighting the need for the integration of scientifically validated complementary therapies into oncological practice, in the context of current challenges related to the rehabilitation of cancer patients. The scientific foundations of using biotechnologies and phytotherapy in integrative oncological medicine are emphasized, through the definition of complementary treatment, the mechanisms involved (immunomodulation, antioxidation, regeneration), and the relevance of the gut-liver-immunity axis.The methodology included criteria for patient selection, administration methods for patented phytotherapeutic products, monitoring parameters (clinical, biochemical, qualitative), and the use of validated tools - functional scores, VAS scales, quality of life (QoL) questionnaires, and laboratory tests.The work is based on original patented contributions of the authors (Prof. Ion Mereuță, Dr. Vladimir Carauș), highlighting relevant patents (number, title, summary), the analysis of formulations (mechanism of action, indications, preclinical studies), and their potential integration into oncological support guidelines. Case studies describe the administration of these formulations to oncology patients during or after chemotherapy, monitoring parameters such as immunity, liver function, nutritional status, and clinical progress.Clinical results indicated a reduction in oxidative stress markers (MDA ↓, SOD and GPx ↑), improvement in liver function (ALT, AST, GGT ↓), enhanced quality of life and adaptability of patients, along with the safety and good tolerability of the treatment.The discussions incorporated scientific correlations with international literature, synergies between patented components, and the importance of standardizing phytopreparations. Arguments were made for including the patented therapies in oncological protocols, emphasizing the necessity of applied research and therapeutic innovation. Proposals were made for extended clinical trials, partnerships, and internationalization initiatives.