Depression and qulity of life in women of reproductive age in the context of surgical menopause

Authors

DOI:

https://doi.org/10.52692/1857-0011.2025.2-82.02

Keywords:

depression, quality of life, urgical menopause

Abstract

Introduction: Surgical menopause, resulting from hysterectomy with or without oophorectomy, leads to a sudden hormonal deficiency that may negatively impact the mental health and quality of life of women of reproductive age. The aim of the study was to analyze the evolution of depressive symptoms in correlation with the quality of life in reproductive-age women after the onset of surgical menopause. Methods: A prospective study involving 150 women divided into three groups: hysterectomy with oophorectomy (L1A), hysterectomy without oophorectomy (L1B), and a control group (L0). Depression and quality of life were assessed at four time points: preoperatively, at 10-12 days, and at 6 and 12 months postoperatively using the Beck Depression Inventory and WHOQOL-BREF. Results: At 12 months, depression was observed in 72% of women in the L1A group and 68% in the L1B group, compared to 16% in the control group. A statistically significant association was found between depression and reduced quality of life, particularly in the L1B group. Conclusions: Hysterectomy in reproductive-age women has a negative impact on mental health and quality of life.Integrating psychological counseling and active follow-up into pre- and postoperative care is recommended.

References

Ghali Nadeen Abu, et al. Prevalence and predictors of depression in Jordanian women post-hysterectomy: A multi-centre cross-sectional study. Sexual & Reproductive Healthcare, 2025, 101113.

Stoller N, Wertli MM, Zaugg TM, Haynes AG, Chiolero A, Rodondi N, et al. Regional variation of hysterectomy for benign uterine diseases in Switzerland. PloS one. 2020;15(5):e0233082.

Manandhar T, Sitaula S, Thapa BD, Agrawal A, Thakur A. Prevalence of hysterectomy among gynecological surgeries in a tertiary care hospital. JNMA: Journal of the Nepal Medical Association. 2020;58(232):965.

Scime NV, Brown HK, Metcalfe A, Brennand EA. Prevalence of hysterectomy by self-reported disability among Canadian women: Findings from a national cross-sectional survey. Women’s Health Reports. 2021;2(1):557-65.

Shahid R, Abbas H, Mumtaz S, Perveen F, Bari MF, Raja T, et al. Hysterectomy and oophorectomy in reproductive age: a cross-sectional study from a tertiary care hospital. Cureus. 2020;12(5).

Baffour Awuah G, Schauberger G, Klug SJ, Tanaka LF. An age-period-cohort analysis of hysterectomy incidence trends in Germany from 2005 to 2019. Scientific Reports. 2024;14(1):15110.

Rajkumari S, Chaudhary V, Kasaudhan S, Saraswathy KN. Incidence and determinants of hysterectomy among North Indian women: An 8-year follow-up study. Frontiers in Public Health. 2022;10:1065081.

Kim H-S, Koo Y-J, Lee D-H. Clinical outcomes of hysterectomy for benign diseases in the female genital tract: 6 years’ experience in a single institute. Yeungnam Univ J Med. 2020;37(4):308-13.

Tanaka LF, Schoffer O, König J, Weyer-Elberich V, Blettner M, Klug SJ. Changes in the probability of hysterectomy in the city of Mainz and Mainz-Bingen region, Germany. BMC Public Health. 2023;23(1):84.

Cernețchi O, Vataman E. Dereglările hormonale după histerectomie. Общественное здоровье, экономика и менеджмент в медицине. 2019(3 (81)):51-4.

Erickson Z, Rocca WA, Smith CY, Rocca LG, Stewart EA, Laughlin-Tommaso SK, et al. Time trends in unilateral and bilateral oophorectomy in a geographically defined American population. Obstetrics & Gynecology. 2022;139(5):724-34.

Kingsberg SA, Larkin LC, Liu JH. Clinical effects of early or surgical menopause. Obstetrics & Gynecology. 2020;135(4):853-68

Wilson L, Pandeya N, Byles J, Mishra G. Hysterectomy and incidence of depressive symptoms in midlife women: the Australian Longitudinal Study on Women’s Health. Epidemiol Psychiatr Sci. 2018;27(4):381-92.

Madueke-Laveaux OS, ElsharoudA,Al-HendyA. What we know about the long-term risks of hysterectomy for benign indication—a systematic review. Journal of clinical medicine. 2021;10(22):5335.

Akbar Neelam; Shah Safia. Frequency of Depression Among Females Underwent Hysterectomy in a Tertiary Care Hospital. In: Medical Forum Monthly. 2024.

Organization WH. Reproductive health indicators: guidelines for their generation, interpretation and analysis for global monitoring. Reproductive health indicators: guidelines for their generation, interpretation and analysis for global monitoring 2006. p. 67.

Bahri N, Tohidinik H, Fathi Najafi T, Larki M, Amini T, Sartavosi Z. Depression Following Hysterectomy and the Influencing Factors. Iranian Red Crescent Medical Journal. 2016;18:e30493

Silva Patrícia Aparecida Barbosa, et al. Cut-off point for WHOQOL-bref as a measure of quality of life of older adults. Revista de saude publica, 2014, 48: 390 - 397.

Choi HG, Rhim CC, Yoon JY, Lee SW. Association between hysterectomy and depression: a longitudinal follow-up study using a national sample cohort. Menopause. 2020;27(5):543-9

Laughlin-Tommaso SK, Satish A, Khan Z, Smith CY, Rocca WA, Stewart EA. Long-term risk of de novo mental health conditions after hysterectomy with ovarian conservation: a cohort study. Menopause. 2020;27(1):33-42.

Gervais NJ, Au A, Almey A, Duchesne A, Gravelsins L, Brown A, et al. Cognitive markers of dementia risk in middle-aged women with bilateral salpingo- oophorectomy prior to menopause. Neurobiol Aging. 2020;94:1-6.

Elweley M, Sabra AI. Psychological problems, Concerns and beliefs in women undergoing hysterectomy. IOSR Journal of Nursing and Health Science. 2015;4(6):48-57.

Vataman E. Menopauza chirurgicală: aspecte psihologice în perioada perioperatorie. Buletinul Academiei de Ştiinţe a Moldovei Ştiinţe Medicale. 2020;66(2):143-7.

Published

2026-03-26

Issue

Section

Research Article

Categories