Fungal allergy – features of molecular diagnosis.
DOI:
https://doi.org/10.52692/1857-0011.2025.3-83.14Keywords:
fungi, sensitization, allergy, molecular diagnosisAbstract
The clinically relevant mold species are Alternaria, Aspergillus, Cladosporium, and Penicillium. The rate of fungal sensitization was 7.7% (26/338) among patients. Most patients with allergic respiratory diseases are sensitized to Alternaria, the fungus with the highest allergenic potential, with a sensitization rate of 5.3% (18/338). Aspergillus second among patients sensitize d to fungi, with a sensitization rate of 2.7% (9/338), followed by Cladosporium with a sensitization rate of 1.2% (4/338). The least frequently implicated in the sensitization of patients with allergic respiratory diseases is Penicillium, with a sensitization rate of 0.9% (3/338).
References
Anees-Hill S., Douglas P., et al. A systematic review of outdoor airborne fungal spore seasonality across Europe and the implications for health. Science of the Total Environment. 2022, nr. 818 pp. 151716.
Ansotegui I.J., Melioli G., et al. A WAO ARIA GA2LEN consensus document on molecular-based allergy diagnosis: Update 2020. World Allergy Organization Journal. 2020, nr. 13 (2), pp. 100091.
Bradshaw N. Go molecular! A clinical reference guide to molecular allergy. Part 1: The basics. 2021, 52 p.
Bradshaw N. Go molecular! A clinical reference guide to molecular allergy. Part 2: The allergen components. 2021, 82 p.
Burks A.W., Holgate S.T., O`Hehir R.E., et al. Middleton`s Allergy. 2020, 1840 p.
Caraballo L., Valenta R., et al. The allergenic activity and clinical impact of individual IgE-antibody binding molecules from indoor allergen sources. World Allergy Organization Journal. 2020, nr. 13 (5),
Dramburg S., Hilger C., et al. EAACI Molecular Allergology User`s Guide 2.0. 2023.
Fukutomi Y., Taniguchi M. Sensitization to fungal allergens: Resolved and unresolved issues. Allergology International. 2015, nr. 64 (4), pp. 321–331.
Hilger C., Villaseñor A., et al. Molecular Allergology Pocket Guide. EAACI 2024, 102 p.
Inamdar A.A., Morath S., Fungal Volatile Organic Compounds: More Than Just a Funky Smell? Annual Review of Microbiology. 2020, nr. 74 (Volume 74, 2020), pp. 101–116.
Lionakis M.S., Drummond R.A., Immune responses to human fungal pathogens and therapeutic prospects. Nature Reviews Immunology. 2023, nr. 23 (7), pp. 433-452.
Matricardi P.M., Kleine-tebbe J., Hoffmann J., et al. Molecular Allergology. 2016.
Oliveira M., Oliveira D., et al. Clinical Manifestations of Human Exposure to Fungi. Journal of Fungi. 2023, nr. 9 (3), pp. 381. ISSN: 2309608X.
Rick E.M., Woolnough K., et al. Allergic fungal airway disease. Journal of Investigational Allergology and Clinical Immunology. 2016, nr. 26 (6), pp. 344-354.
Rodríguez-Fernández A., Aloisi I., et al. Identifying key environmental factors to model Alt a 1 airborne allergen presence and variation. Science of The Total Environment. 2024, nr. 917 pp. 170597.
Shah A., Panjabi C. Allergic Bronchopulmonary Aspergillosis: A Perplexing Clinical Entity. Allergy, Asthma & Immunology Research. 2016, nr. 8 (4), pp. 282- 297.
Downloads
Published
License
Copyright (c) 2026 Bulletin of the Academy of Sciences of Moldova. Medical Sciences

This work is licensed under a Creative Commons Attribution 4.0 International License.
