Allergen-specific immunotherapy in allergic rhinitis: role, mechanisms, and clinical efficacy.
DOI:
https://doi.org/10.52692/1857-0011.2025.3-83.28Keywords:
allergic rhinitis, allergen immunotherapy, SCIT, SLIT, immune tolerance, regulatory T cells, IgG4, IgA, clinical efficacy, ARIA, EAACI, personalized medicineAbstract
This paper provides an updated analysis of the available data on the clinical efficacy, safety profile, indications, and practical implementation of allergen-specific immunotherapy (AIT). The immunological mechanisms are described, highlighting the shift from a Th2-driven proinflammatory response to a tolerant immunologic profile. The role of AIT in reducing symptoms, decreasing medication use, preventing disease progression, and improving quality of life is emphasized.
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