Particularităţile imunologice şi biochimice ale hidrosalpinxului la femeile cu infertilitate

Abstract

The studies carried out have shown the considerable change of biochemical composition of tubal secretion in case of hydrosalpinx: increase of pH and bicarbonates level, decrease of osmolarity, concentration of calcium, glucose and lactate. The results we have obtained allow characterizing the secretion of hydrosalpinx as a biochemically changed, hyperalkaline, hypo-osmolar medium with the low content of microelements and nutrients. The estimation of the concentration of cytokines in the hydrosalpinx fl uid has shown the extremely high secretion of proinfl ammatory cytokines (IL1β, IL6, THF-α), cytokines TH1 (IFNγ, IL-2), and antibodies to cHSP60 in the tubal secretion. At the same time, the component TH2 of the immune system T-helper (IL4) was not activated. Immunological and biochemical imbalance of the tubal secretion has determined the sharp spermatotoxic effect on the migration of spermatozoa in the biological cultures.