Specific changes of cytokine status troughout the processing of acute necrotic pancreatitis in experiment.

Abstract

Using white rats with acute necrotizing pancreatitis and our own experimental model, we studied the changes in TNF-α, IL-2, IL-6 and IL-10 in blood plasma. This proves, that progressing acute necrotizing pancreatitis is characterized by the development of a heavy imbalance of cytokine status with pronounced tendency of anti-inflammatory mediators to be dominate in infl ammation. This contributes to profound immune depression, generalized systemic infectious factors and the development of purulent-necrotizing complications; together, they contribute to death in late stages of the septic process. This justifi es the necessity to develop adequate methods of anti-inflammatory therapy at various stages of acute necrotic pancreatitis.