Specific changes of cytokine status troughout the processing of acute necrotic pancreatitis in experiment.
Ключевые слова:
IL-6, IL-10Аннотация
Using white rats with acute necrotizing pancreatitis and our own experimental model, we studied the changes in TNF-α, IL-2, IL-6 and IL-10 in blood plasma. This proves, that progressing acute necrotizing pancreatitis is characterized by the development of a heavy imbalance of cytokine status with pronounced tendency of anti-inflammatory mediators to be dominate in infl ammation. This contributes to profound immune depression, generalized systemic infectious factors and the development of purulent-necrotizing complications; together, they contribute to death in late stages of the septic process. This justifi es the necessity to develop adequate methods of anti-inflammatory therapy at various stages of acute necrotic pancreatitis.Загрузки
Опубликован
2014-07-23
Выпуск
Раздел
Научная статья
Лицензия
Copyright (c) 2014 Вестник Академии Наук Молдовы. Медицина
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