The role of the oral microbiome in the diagnosis and prognosis of tumors of the oral cavity

Authors

  • Spinei Aurelia USMF „Nicolae Testemițanu”, Republica Moldova
  • Chiriac Anca Institutul de Chimie Macromoleculară „Petru Poni”, Iași, România
  • Spinei Iurie USMF „Nicolae Testemițanu”, Republica Moldova
  • Ţîbîrnă Gheorghe USMF „Nicolae Testemițanu”, Republica Moldova

DOI:

https://doi.org/10.52692/1857-0011.2021.2-70.09

Keywords:

oral microbiome, biofilm, oral cancer, inflammation, biomarker

Abstract

Role of oral microbiome in diagnosis and prognosis of oral tumors (literature review). Despite advancement in tumors treatment, oral cancer has a poor prognosis and is often detected at late stage. Recent advancement in metagenomic technologies may be useful in identifying oral tumors–related microbiome, their genomes, virulence properties, and their interaction with host immunity. Alteration in the oral commensal microbial communities have potential application as a diagnostic tool to predict oral tumors. To develop highly precise and effective therapeutic approaches, identification of specific oral microbiomes may be required. In this review, we narrate the role of microbiome in the progression of oral tumors and its role as an early diagnostic and prognostic biomarker for oral tumors

Author Biographies

Spinei Aurelia, USMF „Nicolae Testemițanu”, Republica Moldova

dr. hab. șt. med., prof. univ

Chiriac Anca, Institutul de Chimie Macromoleculară „Petru Poni”, Iași, România

prof. univ., dr. med

Spinei Iurie, USMF „Nicolae Testemițanu”, Republica Moldova

dr. șt. med., conf. univ

Ţîbîrnă Gheorghe, USMF „Nicolae Testemițanu”, Republica Moldova

acad., dr. hab. șt. med., prof. univ

Published

2021-06-25