The role of the oral microbiome in the diagnosis and prognosis of tumors of the oral cavity

Authors

  • Spinei Aurelia USMF „Nicolae Testemițanu”, Republica Moldova
  • Chiriac Anca Institutul de Chimie Macromoleculară „Petru Poni”, Iași, România
  • Spinei Iurie USMF „Nicolae Testemițanu”, Republica Moldova
  • Ţîbîrnă Gheorghe USMF „Nicolae Testemițanu”, Republica Moldova

DOI:

https://doi.org/10.52692/1857-0011.2021.2-70.09

Keywords:

oral microbiome, biofilm, oral cancer, inflammation, biomarker

Abstract

Role of oral microbiome in diagnosis and prognosis of oral tumors (literature review). Despite advancement in tumors treatment, oral cancer has a poor prognosis and is often detected at late stage. Recent advancement in metagenomic technologies may be useful in identifying oral tumors–related microbiome, their genomes, virulence properties, and their interaction with host immunity. Alteration in the oral commensal microbial communities have potential application as a diagnostic tool to predict oral tumors. To develop highly precise and effective therapeutic approaches, identification of specific oral microbiomes may be required. In this review, we narrate the role of microbiome in the progression of oral tumors and its role as an early diagnostic and prognostic biomarker for oral tumors

Author Biographies

Spinei Aurelia, USMF „Nicolae Testemițanu”, Republica Moldova

dr. hab. șt. med., prof. univ

Chiriac Anca, Institutul de Chimie Macromoleculară „Petru Poni”, Iași, România

prof. univ., dr. med

Spinei Iurie, USMF „Nicolae Testemițanu”, Republica Moldova

dr. șt. med., conf. univ

Ţîbîrnă Gheorghe, USMF „Nicolae Testemițanu”, Republica Moldova

acad., dr. hab. șt. med., prof. univ

References

Gupta B., Johnson N. Systematic review and meta-analysis of association of smokeless tobacco and of betel quid without tobacco with incidence of oral cancer in South Asia and the Pacific. PLoS One, 2014; 9(11):e113385.

Lax A., Thomas W. How bacteria could cause cancer: one step at a time. Trends Microbiol., 2012; 10(6):293-299.

Multhoff G., Molls M., Radons J. Chronic inflammation in cancer development. Front Immunol., 2011; 2:98.

Perera M., Al-hebshi N., Speicher D., Perera I., Johnson N. Emerging role of bacteria in oral carcinogenesis: a review with special reference to perio-pathogenic bacteria. J Oral Microbiol., 2016; 8(1):32762.

Dewhirst F., Chen T., Izard J., et al. The human oral microbiome. J Bacteriol., 2010; 192(19):5002-5017.

Lim Y., Totsika M., Morrison M., Punyadeera C. Oral microbiome: a new biomarker reservoir for oral and oropharyngeal cancers. Theranostics., 2017; 7(17):4313-4321.

Dawes C. Estimates, from salivary analyses, of the turnover time of the oral mucosal epithelium in humans and the number of bacteria in an edentulous mouth. Arch Oral Biol., 2003; 48(5): 329-336.

Avila M., Ojcius D., Yilmaz O. The oral microbiota: living with a permanent guest. DNA Cell Biol., 2009; 28(8):405-411.

Mager D., Haffajee A., Devlin P., et al. The salivary microbiota as a diagnostic indicator of oral cancer: a descriptive, nonrandomized study of cancer-free and oral squamous cell carcinoma subjects. J Transl Med., 2005; 3(1):27.

Itzek A., Gillen C., Fulde M., et al. Contribution of plasminogen activation towards the pathogenic potential of oral Streptococci. PLoS One., 2010; 5(11):e13826.

Lamont R., Koo H., Hajishengallis G. The oral microbiota: dynamic communities and host interactions. Nat Rev Microbiol., 2018; 16(12):745-759.

Chen T., Yu W., Izard J., et al. The human oral microbiome database: a web accessible resource for investigating oral microbe taxonomic and genomic information. Database (Oxford)., 2010; 2010:baq013.

Jakubovics N., Kolenbrander P. The road to ruin: the formation of disease-associated oral biofilms. Oral Dis., 2010; 16(8): 729-739.

Aruni A., Dou Y., Mishra A., Fletcher H. The biofilm community—Rebels with a cause. Curr Oral Health Rep., 2015; 2(1): 48-56.

Sintim H., Gu¨rsoy U. Biofilms as “Connectors” for oral and systems medicine: a new opportunity for biomarkers, molecular targets, and bacterial eradication. OMICS., 2016; 20(1):3-11.

Zhang K., Ou M., Wang W., Ling J. Effects of quorum sensing on cell viability in Streptococcus mutans biofilm formation. Biochem Biophys Res Commun., 2009; 379(4):933-938.

Baker J., Bor B., Agnello M., Shi W., He X. Ecology of the oral microbiome: beyond bacteria. Trends Microbiol., 2017; 25(5): 362-374.

Rosier B., Marsh P, Mira A. Resilience of the oral microbiota in Health: mechanisms that prevent dysbiosis. J Dent Res., 2018; 97(4):371-380.

Zaura E., Keijser B., Huse S., Crielaard W. Defining the healthy “core microbiome” of oral microbial communities. BMC Microbiol., 2009; 9:259.

Verma M. Mechanistic and Technical Challenges in Studying the Human Microbiome and Cancer Epidemiology. Technol Cancer Res Treat., 2017; 16(2):150-158.

Acharya A., Chan Y., Kheur S., et al. Salivary microbiome of an urban Indian cohort and patterns linked to subclinical inflammation. Oral Dis., 2017; 23(7):926-940. doi: 10.1111/ odi.12676.

Sarkar A., Stoneking M., Nandineni M. Unraveling the human salivary microbiome diversity in Indian populations. PLoS One., 2017; 12(9):e0184515.

Sivan A., Corrales L., Hubert N., et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science., 2015; 350(6264):10841089.

Gholizadeh P., Eslami H., Kafil H. Carcinogenesis mechanisms of Fusobacterium nucleatum. Biomed Pharmacother., 2017; 89: 918-925.

Laprise C., Shahul H., Madathil S., et al. Periodontal diseases and risk of oral cancer in Southern India: results from the HeNCe life study. Int J Cancer., 2016; 139(7):1512-1519.

Yao Q., Zhou D., Peng H., et al. Association of periodontal disease with oral cancer: a meta-analysis. Tumor Biol., 2014; 35(7):7073-7077.

Shi B., Chang M,. Martin J., et al. Dynamic changes in the subgingival microbiome and their potential for diagnosis and prognosis of periodontitis. MBio., 2015;6(1):e01926-14. doi: 10.1128/ mBio.01926-14.

Hajishengallis G. Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response. Trends Immunol., 2014; 35(1):3-11.

Gao L., Xu T., Huang G., et al. Oral microbiomes: more and more importance in oral cavity and whole body. Protein Cell., 2018; 9(5):488-500. doi: 10.1007/s13238018-0548 -1.

Wang K., Lu W., Tu Q., et al. Preliminary analysis of salivary microbiome and their potential roles in oral lichen planus. Sci Rep., 2016; 6:22943.

Lee W., Chen H., Yang S., et al. Bacterial alterations in salivary microbiota and their association in oral cancer. Sci Rep., 2017; 7(1):1-11.

Furquim C., Soares G., Ribeiro L., et al. The salivary microbiome and oral cancer risk: a pilot study in Fanconi anemia. J Dent Res., 2017; 96(3):292-299.

Guerrero-Preston R., Godoy-Vitorino F., Jedlicka A., et al. 16 S rRNA amplicon sequencing identifies microbiota associated with oral cancer, human papilloma virus infection and surgical treatment. Oncotarget., 2016; 7(32):51320-51334.

Guerrero-Preston R., White J.R., Godoy-Vitorino F., et al. Highresolution microbiome profiling uncovers Fusobacterium nucleatum, Lactobacillus gasseri/johnsonii, and Lactobacillus vaginalis associated to oral and oropharyngeal cancer in saliva from HPV positive and HPV negative patients treated with surgery and chemo-radiation. Oncotarget., 2017 ;8(67):110931-110948. doi: 10.18632/oncotarget.20677.

Karpin´ski T. Role of Oral microbiota in cancer development. Microorganisms., 2019; 7(1):pii E20.

Bo¨rnigen D., Ren B., Pickard R., et al. Alterations in oral bacterial communities are associated with risk factors for oral and oropharyngeal cancer. Sci Rep., 2017; 7(1):17686. doi:10.1038/s41598017-17795-z

Al-Hebshi N., Nasher A., Maryoud M., et al. Inflammatory bacteriome featuring Fusobacterium nucleatum and Pseudomonas aeruginosa identified in association with oral squamous cell carcinoma. Sci Rep., 2017; 7(1):1834. doi: 10.1038/s41598-01702079-3.

Lim Y., Fukuma N., Totsika M., et al. The performance of an oral microbiome biomarker panel in predicting oral cavity and oropharyngeal cancers. Front Cell Infect Microbiol., 2018; 8:267.

Hayes R., Ahn J., Fan X., et al. Association of oral microbiome with risk for incident head and neck squamous cell cancer. JAMA Oncol., 2018; 4(3):358-365. doi: 10.1001/jamaoncol.2017.4777.

Al-Hebshi N., Alharbi F., Mahri M., Chen T. Differences in the bacteriome of smokeless tobacco products with different oral carcinogenicity: compositional and predicted functional analysis. Genes., 2017a; 8:106. doi: 10.3390/genes8040106.

Meurman JH. Oral microbiota and cancer. J Oral Microbiol., 2010; 2. doi: 10.3402/jom.v2i0.5195.

Kang M., Oh J., Kim H., et al. Prevalence of oral microbes in the saliva of oncological patients. J Bacteriol Virol., 2009; 39(4): 277-285.

Hiranmayi K., Sirisha K., Ramoji Rao M., Sudhakar P. Novel pathogens in periodontal microbiology. J Pharm Bioallied Sci., 2017; 9(3):155-163.

Ganly I., Yang L., Giese R., et al. Periodontal pathogens are a risk factor of oral cavity squamous cell carcinoma, independent of tobacco and alcohol and human papillomavirus. Int J Cancer., 2019; 145(3):775-784.

Banerjee S., Tian T., Wei Z., et al. Microbial signatures associated with oropharyngeal and oral squamous cell carcinomas. Sci Rep., 2017; 7(1):4036.

Perera M., Al-Hebshi N., Perera I., et al. Inflammatory bacteriome and oral squamous cell carcinoma. J Dent Res., 2018; 97(6): 725-732. doi: 10.1177/0022034518767118.

Gaonkar P., Patankar S., Tripathi N., Sridharan G. Oral bacterial flora and oral cancer: The possible link? J Oral Maxillofac Pathol., 2018; 22(2):234-238.

Hsiao J., Chang C., Lee W., et al. The interplay between oral microbiome, lifestyle factors and genetic polymorphisms in the risk of oral squamous cell carcinoma. Carcinogenesis., 2018; 39(6):778-787.

Vesty A., Gear K., Biswas K., et al. Microbial and inflammatory-based salivary biomarkers of head and neck squamous cell carcinoma. Clin Exp Dent Res., 2018; 4(6):255-262.

Singleton D., Adrion A., Aitken M. Surfactant-induced bacterial community changes correlated with increased polycyclic aromatic hydrocarbon degradation in contaminated soil. Appl Microbiol Biotechnol., 2016; 100(23):10165-10177.

Vogelmann R., Amieva M. The role of bacterial pathogens in cancer. Curr Opin Microbiol., 2007; 10(1):76-81.

Gholizadeh P., Eslami H., Yousefi M., et al. Role of oral microbiome on oral cancers, a review. Biomed Pharmacother., 2016; 84:552-558. doi: 10.1016/j.biopha. 2016.09.082.

Yang S., Huang H., Fan W., et al. Compositional and functional variations of oral microbiota associated with the mutational changes in oral cancer. Oral Oncol., 2018; 77:1-8.doi: 10.1016/j. oraloncology.2017.12.005.

Spinei A., Spinei I., Țîbîrnă Gh. Terapia fotodinamică antimicrobiană o strategie pentru prevenirea cariilor dentare la copii. Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţe Medicale. Chişinău., 2019; 4(64): 182-190.

Published

2021-09-25

Issue

Section

Research Article