Juvenile laryngeal papillomatosis
DOI:
https://doi.org/10.52692/1857-0011.2023.2-76.08Keywords:
juvenile papillomatosis, larynx, stridorAbstract
Laryngeal papillomatosis is a benign tumor, resulting from the conjunctival epithelial proliferation of the laryngeal mucosa. It is an evolutionary, recurrent and extensive pathology of human papillomavirus, especially type 6 and 11, that are the most related and aggressive. The treatment is a multimodal one, the basic being the suspended microlaringoscopy with excision of the papillomas. Were used data from the literature with reference to laryngeal papillomatosis and statistics during 2010-2022 years in the Clinical „Emilian Coțaga”, ENT Clinic. During this time were registered 56 patients with the diagnosis of laryngeal papillomatosis. The prevalence of F / M sex is 8: 5. Out of the total number of addresses, the age of the patients was between 1-13 years, of which in 5 patients, the age was 2 years. In children, papillomas are multiple and recur frequently after ablation, compared to the adult, in which it is usually singular, but can degenerate into malignancy. In some cases, in children, papillomas may recede spontaneously after puberty.
References
Ababii I., Cabac V., Danilov L., Osman V. Papiomatoza laringelui la copii – experienţa Clinicii ORL pentru copii. Conf. Naţ. ORL cu participare internaţ. Vol. de rezum. Constanţa. 29 apr.-1 mai. 2007. p.41-42.
Armstrong, L.R., C.S. Derkay, and W.C. Reeves, Initial results from the national registry for juvenile-onset recurrent respiratory papillomatosis. RRP Task Force. Arch Otolaryngol Head Neck Surg, 1999. 125(7): p. 743-8.
Brophy JW, Scully PA, Stratton CJ. Argon laser use in papillomas of the larynx. Laryngoscope 1982;92(10 Pt 1):1164-7.
Derkay C. S. Darrow D. Recurrent Respiratory Papillomatosis. Ann Otol Rhinol Laryngol., 2006; 115:1-11.
Maloney, E.M., et al., Longitudinal measures of human papillomavirus 6 and 11 viral loads and antibody response in children with recurrent respiratory papillomatosis. Arch Otolaryngol Head Neck Surg, 2006. 132(7): p. 711-5.
Grøn AL, Schultz JH, Abildgaard J. Malignant degeneration in laryngeal papillomatosis. Ugeskr Laeger., 2011; 173(7):506-7.
Kanazawa T., Fukushima N., Imayoshi Sh., et al. Rare case of malignant transformation of recurrent respiratory papillomatosis associated with human papillomavirus type 6 infection and p53 overexpression. Springer Plus, 2013, 2:153-61.
Leung R., M. Hawkes and P. Campisi. Severity of juvenile onset recurrent respiratory papillomatosis is not associated with socioeconomic status in a setting of universal health care. Int J Pediatr Otorhinolaryngol, 2007. 71(6): p. 965-72.
Bjeldanes LF, Kim JY, Grose KR, Bartholomew JC, Bradfield CA. Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Proc Natl Acad Sci U S A 1991;88(21):9543-7.
Chadha N.K., et al., The quality of life and health utility burden of recurrent respiratory papillomatosis in children. Otolaryngol Head Neck Surg, 2010. 143(5): p. 685-90.
Hermann J.S., Pontes P., Weckx L.M., Reginaldo Fujita R., Avelino M., Pignatari S.S.N. Laryngeal sequelae of recurrent respiratory papillomatosis surgery in children. Original article. Rev Assoc.Med. Bras., 2012; 58(2):204-208.
Ilmarinen T, Nissilä H, Rihkanen H, Roine RP, Pietarinen-Runtti P, Pitkäranta A, Aaltonen LM. Clinical features, health-related quality of life, and adult voice in juvenile-onset recurrent respiratory papillomatosis. The Laryngoscope, 2011; 121(4):846-51.
Kashima H, Mounts P, Leventhal B, Hruban RH. Sites of predilection in recurrent respiratory papillomatosis. Ann Otol Rhinol Laryngol 1993;102(8 Pt 1):580-3.
Bishai D, Kashima H, Shah K. The cost of juvenile-onset recurrent respiratory papillomatosis. Arch Otolaryngol Head Neck Surg 2000;126(8):935-9.
Buchinsky, F.J., et al., Age of child, more than HPV type, is associated with clinical course in recurrent respiratory papillomatosis. PLoS One, 2008. 3(5): p. e2263.
Rimell F.L., et al., Pediatric respiratory papillomatosis: prognostic role of viral typing and cofactors. Laryngoscope, 1997. 107(7): p. 915-8.
Wiatrak B.J., et al., Recurrent respiratory papillomatosis: a longitudinal study comparing severity associated with human papilloma viral types 6 and 11 and other risk factors in a large pediatric population. Laryngoscope, 2004. 114(11 Pt 2 Suppl 104): p. 1-23.
François M. Papillomatose laryngée. Encyclopédie medico-chirurgicale 20-705A-10. Editions scientifiques et médicales Elsevier 2000.
Gerein V., et al. Incidence, age at onset, and potential reasons of malignant transformation in recurrent respiratory papillomatosis patients: 20 years experience. Otolaryngol Head Neck Surg, 2005. 132(3): p. 392-4.
Draganov P., et al., Identification of HPV DNA in patients with juvenile-onset recurrent respiratory papillomatosis using SYBR Green real-time PCR. Int J Pediatr Otorhinolaryngol, 2006. 70(3): p. 469-73.
Pou A.M., et al., Molecular characterization of mutations in patients with benign and aggressive recurrent respiratory papillomatosis: a preliminary study. Ann Otol Rhinol Laryngol, 2004. 113: p. 180-6.
Rabah R., et al., Human papillomavirus-11-associated recurrent respiratory papillomatosis is more aggressive than human papillomavirus-6-associated disease. Pediatr Dev Pathol, 2001. 4(1): p. 68-72.
Reidy P.M., et al., Integration of human papillomavirus type 11 in recurrent respiratory papilloma-associated cancer. Laryngoscope, 2004. 114(11): p. 1906-9.
Campisi P., M. Hawkes, and K. Simpson, The epidemiology of juvenile onset recurrent respiratory papillomatosis derived from a population level national database. Laryngoscope, 2010. 120(6): p. 1233-45.
Reeves W.C., et al., National registry for juvenile-onset recurrent respiratory papillomatosis. Arch Otolaryngol Head Neck Surg, 2003. 129(9): p. 976-82.
Shehata B.M., et al., E6 and E7 oncogene expression by human papilloma virus (HPV) and the aggressive behavior of recurrent laryngeal papillomatosis (RLP). Pediatr Dev Pathol, 2008. 11(2): p. 118-21.
Snowden R.T., et al., The predictive value of serum interleukins in recurrent respiratory papillomatosis: a preliminary study. Laryngoscope, 2001. 111(3): p. 404-8.
Bergler W, Honig M, Gotte K, Petroianu G, Hormann K. Treatment of recurrent respiratory papillomatosis with argon plasma coagulation. J Laryngol Otol 1997;111(4):3814.
Bonagura VR, Hatam L, DeVoti J, Zeng F, Steinberg BM. Recurrent respiratory papillomatosis: altered CD8(+) T-cell subsets and T(H)1/T(H)2 cytokine imbalance. Clin Immunol 1999;93(3):302-11.
Lindeberg H, Elbrond O. Laryngeal papillomas: the epidemiology in a Danish subpopulation 1965-1984. Clin. Otolaryngol. Allied. Sci., 1999; 15: 125–131.
Bell R, Hong WK, Itri LM, McDonald G, Strong MS. The use of cis-retinoic acid in recurrent respiratory papillomatosis of the larynx: a randomized pilot study. Am J Otolaryngol 1988;9(4):161-4.
Baron S, Tyring SK, Fleischmann WR, Jr., Coppenhaver DH, Niesel DW, Klimpel GR, et al. The interferons. Mechanisms of action and clinical applications. Jama 1991;266(10):1375-83.
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