EXPERIMENTAL STUDY OF THE USE OF OSTEO-CELLULAR GRAFTS IN WRIST ARTHRODESIS
DOI:
https://doi.org/10.52692/1857-0011.2023.2-76.21Keywords:
wrist arthrodesis, autologous stem cells, osteo-cellular graftAbstract
Introduction. Wrist arthrodesis is a surgery performed in advanced osteoarthritis of the wrist joint of various etiology, posttraumatic consequences or diseases of carpal bones. It is a rescue surgery and is performed with the cost of losing of range of movement, but remove the pain syndrome and increase the strength of the hand. Aim of study. Evaluation of osteo-cellular grafts (OCG) using in wrist arthrodesis in experimental study on laboratory animals. Material and Methods. The study was based on experimental research on 21 New Zealand rabbits, splited in 3 study groups. As methods of implementation of the study included: preparation of allogeneic demineralized bone grafts, bone marrow sampling and isolation of autologous stem cells, obtaining OCG, and performing 3 different techniques of wrist arthrodesis. Results. Imagistic results showed us, that the group were performed arthrodesis using combined graft with stem cells, the ankylosis were achieved faster. Histological examinations indicated more active involvement in the process of osteogenesis in the use of combined stem cell transplantation. Conclusion. Our study showed that compared to the control group, the arthrodesis of the wrist using the allograft have good impact in the process of osteogenesis, but the best results were performed by using allograft combined with stem cells.
References
Britannica, The Editors of Encyclopaedia. „wrist”. Encyclopedia Britannica, 30 Aug. 2018, https://www.britannica.com/science/wrist-anatomy.
Linscheid RL, dobyns JH, beabout JW, bryan RS. Traumatic instability of the wrist. Diagnosis, classification, and pathogenesis. J Bone Joint Surg AM. 1972;54:1612–1632.
Carlsen, B. T., Shin A. Y. Wrist instability. Scandinavian Journal of Surgery 97: 324–332, 2008
Lichtman DM, Martin RA: Introduction to the carpal instabilities. the wrist and its disorders, Ed. D.M. Lichtman. 1988, WB Saunders: Philadelphia, pp. 245–250.
Taqi M, Lim Y. Wrist Instability. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022 Jan. https://www.ncbi.nlm.nih.gov/books/NBK572073/
Taleisnik J (Ed):the wrist. Churchill Livingstone, New York,1985
Gajdoš R , Pilný J, Pokorná A. Injury to the Scapholunate Ligament in Distal Radius Fractures: PeriOperative Diagnosis and Treatment Results. Acta Chir Orthop Traumatol Cech. 2016;83(5):336343
Luchetti, I. Papini Zorli, A. Atzei, T. Fairplay. Dorsal intercarpal ligament capsulodesis for predynamic and dynamic scapholunate instability. The Journal of Hand Surgery (2009) 0: 0: 1–6.
Kulhawik D, Szałaj T, Grabowska M. Avascular necrosis of the lunate bone (Kienböck’s disease) secondary to scapholunate ligament tear as a consequence of traumaa case study. Pol J Radiol. 2014;79: 24-6.
Lesley N, Lichtman D. Klassifikation und Behandlung des Morbus Kienböck: Eine Ubersicht über die vergangenen 100 Jahre und ein Blick in die Zukunft [Classification and treatment of Kienbock disease: a review of the past 100 years, and a look at the future]. Handchir Mikrochir Plast Chir. 2010 Jun;42(3):171-6. German. doi: 10.1055/s-0030-1249611. Epub 2010 May 5. PMID: 20446244.
Nasr LA, Koay J. Kienbock Disease. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK536991/
Babiuc, C. Reumatologie clinică. Edit. Tipografia Centrală, Chișinău, 2010, 392 p.
Caggiano N, Matullo KS. Carpal instability of the wrist. Orthop Clin North Am. 2014 Jan;45(1):129-40. doi: 10.1016/j.ocl.2013.08.009. Epub 2013 Oct 1. PMID: 24267214.
Azócar C, Lecaros JJ, Bernal N, Sanhueza M, Liendo R, Cifras JL. Four-Corner Arthrodesis: Comparative Analysis of Open Technique Versus Percutaneous Technique with Arthroscopic Assistance. J Wrist Surg. 2021 Oct 1;11(2):127-133. doi: 10.1055/s-0041-1735838. PMID: 35478943; PMCID: PMC9038305.
Anikar Chhabra, Jonathan E. ISAACS. Arthritis and Arthroplasty: The Hand, Wrist, and Elbow. Elsevier Health Sciences, Jan 1, 2010, 312 pages, pp. 126-130.
Watson, H.K., Ballet, F.L. The SLAC wrist: scapholunate advanced collapse pattern of degenerative arthritis. J. Hand. Surg. (Am.), 1984 (9A); 358-365.
Richard H. Gelberman, William P. Cooney, M. Szabo. Carpal Instability. J Bone Joint Surg Am. 2000:82:578.
Melone C.P., Murphz, M.S., Raskin, K.B. Perilunate injuries: repair by dual dorsal an volar approaches. In: Hand Clinics, 2000, nr. 16, p. 439-448.
Dobyns JH, Cooney WP: Classification of carpal instability. The wrist: diagnosis and operative treatment, Ed: W.P. Cooney, R. L. Linscheid, and J.H. Dobyns. Vol. 1. 1998, St. Louis: Mosby pp. 490–500
Buzu, D., Vacarciuc, I., Ursu, S., Maftei, D. Tratamentul chirurgical al luxaţiilor şi fracturilor. Luxaţii ale oaselor carpiene. Sănătate Publică și Management în Medicină, Chișinău, 2014, p. 28-30.
Iacubitchii, V., Cobzac, V., Cociug, A. Capros, N. Selective wrist arthrodesis: standard vs combined graft with stem cells. Experimental research. In: Abstract book the 9th International Medical Congress for Students and Young Doctors MedEspera 2022, Chișinău, Republica Moldova, 12-14 Mai 2022, p. 467. ISBN 978-9975-3544-2-4.
Huang, Jerry I. MD1; Durbhakula, Mahidhar M. MD1; Angele, Peter MD1; Johnstone, Brian PhD1; Yoo, Jung U. MD1. Lunate Arthroplasty with Autologous Mesenchymal Stem Cells in a Rabbit Model. The Journal of Bone & Joint Surgery 88(4):p 744-752, April 2006. | DOI: 10.2106/JBJS.E.00669
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