The Impact of Uric Acid Levels on the Risk of Chronic Respiratory Diseases: Analysis of Age and Gender Differences
DOI:
https://doi.org/10.52692/1857-0011.2024.2-79.06Keywords:
uric acid, hronic respiratory diseases, COPD, bronchial asthma, inflammation, metabolic markers, lung functionAbstract
This study aims to investigate the role of serum uric acid and urea as potential risk factors for chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and bronchial asthma. Uric acid, as the end product of purine metabolism, has dual properties: at normal concentrations, it acts as an antioxidant that protects cells from oxidative stress, but at elevated levels, it becomes a pro-oxidant, potentially enhancing inflammatory processes and tissue damage.The study analyzed data from patients with obstructive respiratory diseases, including levels of uric acid, and lung function indicators (FEV1, FVC, FEV1/FVC). It also examined gender and age differences, and inclusion and exclusion criteria were established to create a more homogeneous sample.The main findings indicate that elevated uric acid levels are associated with reduced lung function and may serve as an indicator of disease severity. Additionally, a significant link was found between hyperuricemia and inflammatory processes, supported by the activation of pro-inflammatory signaling pathways. Uric acid levels were found to be higher in men, suggesting a higher predisposition to respiratory diseases.
References
Ford, E. S., & Li, C. (2006). Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents. Circulation, 113(19), 2473- 2478.
Kanbay, M., Jensen, T., Solak, Y., Le, M., Roncal- Jimenez, C., &Lanaspa, M. A., et al. (2016). Uric acid in metabolic syndrome: From an innocent bystander to a central player. European Journal of Internal Medicine, 29, 3-8.
Zuo, T., Liu, X., & Li, Y. (2016). Serum uric acid and impaired lung function in a Chinese population: A cross- sectional study. Respiratory Medicine, 120, 28-34.
Kuwabara, M., Niwa, K., Nishihara, S., Nishi, Y., Takahashi, O., &Hisatome, I. (2017). Hyperuricemia is an independent competing risk factor for atrial fibrillation. Circulation Journal, 81(4), 509-514.
Horsfall LJ, Nazareth I, Petersen I. Serum uric acid and the risk of respiratory disease: apopulation- basedcohortstudy. Thorax 2014;69:1021-1026.
El Ridi, R., &Tallima, H. (2017). Physiological functions and pathogenic potential of uric acid: A review. Journal of Advanced Research, 8(5), 487-493.
Liu, L., Lou, Y., Cui, H., & Xie, X. (2018). Association between hyperuricemia and the risk of chronic obstructive pulmonary disease: A cross-sectional study. International Journal of Chronic Obstructive Pulmonary Disease, 13, 2495-2500.
Nicks, M. E., & O’Brien, M. M. (2019). Uric acid and lung disease. Current Opinion in Pulmonary Medicine, 25(2), 125-129.
Zhang, Y., Qiu, H., He, J., Zhang, Q., Lei, S., & Zhang,X. (2020). Association of serum uric acid with the risk of metabolic syndrome and impaired lung function: A systematic review and meta-analysis. BMC Endocrine Disorders, 20(1), 1-9.
Chang, H. H., & Lin, C. H. (2021). Serum uric acid levels and chronic obstructive pulmonary disease: A population- based study. Respiratory Research, 22(1), 1-9.
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