THE IMPORTANCE OF GUT MICROBIOTA IN PERSONALIZED APPROACH FOR OBESITY
DOI:
https://doi.org/10.52692/1857-0011.2025.2-82.40Keywords:
obesity, gut microbiota, personalized medicineAbstract
Introduction. The impact of intestinal microflora on various processes, including metabolic, immune, and inflammatory processes, has been proven. Considering an individual’s intestinal microbiome profile could influence the personalized approach to obesity management. Materials and methods. A conducted literature review used the PubMed and Google Scholar search engines to select full versions of articles in English from 2019 to 2025. Results. Numerous studies confirm the importance of maintaining the variability of the gut microbiome in obesity management. Particular attention is given to personalized nutrition for managing or preventing the disease. Intestinal dysbiosis develops as a result of a diet low in fiber and high in fat and animal protein; a sedentary lifestyle; exposure to toxic substances (pesticides), etc. Dysbiosis induces epigenetic changes, such as DNA methylation, non-coding RNA, and chromatin remodeling having negative effects on the epigenome and causing disturbances in carbohydrate and lipid metabolism. Individual restoration of intestinal balance is possible through molecular-genetic methods with the identification of intestinal microflora diversity and the subsequent implementation of personalized interventions. Conclusion. The personalized approach to people with obesity is aimed at increasing the diversity of the intestinal microbiome through various methods. These interventions are based on personalized nutrition and on interventions such as activity regimens, administration of prebiotics, probiotics, postbiotics, or symbiotics, and fecal microbiota or bacteriophage transplantation, in addition to many other surgical, therapeutic, and behavioral interventions for the personalized treatment of obesity.
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