Ulcerative colitis in children: contemporary views of diagnostic and therapeutic management

Authors

  • Tatiana RABA Nicolae Testemițanu State University of Medicine and Pharmacy https://orcid.org/0000-0002-3970-6495
  • Olga TIHAI Public Medical and Sanitary Institution “Institute of Mother and Child”
  • Ion MIHU Public Medical and Sanitary Institution “Institute of Mother and Child”
  • Ludmila BOLOGA Nicolae Testemițanu State University of Medicine and Pharmacy
  • Doina BIVOL Nicolae Testemițanu State University of Medicine and Pharmacy

DOI:

https://doi.org/10.52692/1857-0011.2025.2-82.42

Keywords:

inflammatory bowel disease, ulcerative colitis, children

Abstract

Ulcerative colitis (UC) in children is a chronic inflammatory disease of the colon that belongs to the group of inflammatory bowel diseases (IBD) with a increasing global incidence rate. Effective diagnosis and treatment of pediatric UC require adherence to and application of a comprehensive multidisciplinary approach. Treatment of UC in children is aimed at achieving clinical and laboratory remission, reducing the activity of the inflammatory process with drug therapy, the phased use of modern biological agents and in the event of complications, surgical intervention. This article analyzes modern practical approaches to solving these problems and analyzes modern strategies for treating emergency conditions in children in the context of updated international guidelines.

References

Kucharzik T., Dignass A., Atreya R. et al. Aktualisiete S3-leitline Colitis ulcerosa (version 6.2). Z gastroenterol., 2024 may; 62(5):769-858. doi: 10.1055/a-2271-0994. Epub 2024 May 8.

Long D. Crohn’s disease and ulcerative colitis: from pathophysiology to novel therapeutic approaches. Biomedicines. 2024, 1293), 689; doi.org/10.3390/ biomedicines12030689. PMC, PubMed.

Calvez V., Puca P., Di Vincenzo F., Del Gaudio A., Bartocci B. et al. Novel Insights into the Pathogenesis of Inflammatory Bowel Diseases. Biomedicines. 2025, Jan 26; 13(2):305. doi:10.3390/ biomedicines13020305.

Güler S., Aksoy B., Appak Y. Ç., Kahveci S., Karabağ Ş. O. Et al. The Effect of the COVID-19 Pandemic on the Frequency and Course of Inflammatory Bowel Disease in Children. J Pediatr Infect Dis, 2023; 18(05): 227-231. DOI:10.1055/s-0043-1769738.

Garg H. K., Shashi K.K., Kurian J., Winant A. J., Lee EY. MR Enterography: Beyond Inflammatory Bowel Disease. Radiol Clin North Am. 2025 Sep;63(5):781- 789. doi: 10.1016/j.rcl.2025.03.011. Epub 2025 Apr 11. PMID: 40713442

Zong W., Patel A., Chang V., Mitchel E. B., Stoner N. et al. Clinical and lifestyle patterns in Asian children with inflammatory bowel disease in the U.S. PloS One, 2023, Mar 22; 18(3):e0281949. doi: 10.1371/journal. pone.0281949.

Liao H. T. (J), Knipe H. Paris Classification of inflammatory bowel disease. 9 jan 2023. DOI: 10.53347/rID-159420. www.radiopaedia.org.

Kong L., Pokatayev V., Lefkovith A., Carter G. T., Creasey E. A. et al. The Landscape of Immune Dysregulation in Crohn’s Disease Revealed through Single-Cell Transcriptomic Profiling in the Ileum and Colon. Immunity. 2023;56:444–458.e5. doi: 10.1016/j.immuni.2023.01.002.

Adi Eindor‐Abarbanel A., Meleady L., Lawrence S., Hamilton Z. et al. Progression to Anti‐TNF Treatment in Very Early Onset Inflammatory Bowel Disease Patients. Journal of Pediatric Gastroenterology and Nutrition, 2022, 75(4), 473-479. https://doi.org/10.1097/MPG.0000000000003551

Vinsard D. G., Raffals L. H., Bruining D. H. et al. Interobserver agreement of paris classification and modified Paris clasiffication of colorectal lesions in patients with inflamatory bowel disease. A multicenter international study. Gastrointestinal Endoscopy, June 2022, volume 95, Issue 6, AB196 - AB197. https://www.giejournal.org/article/S0016-5107(22)00818-5

Jabandziev P., Pinkasova P., Kunovsky L., Papez J., Louza M. et al. Regional incidence of inflammatory bowel disease in a Czeh pediatric population: 16 years of experience (2002-2017). Journal of Pediatric Gastroenterology and Nutrition, vol. 70, Issue 5, May 2020; pp.539-717, e88-e110. www.jpgn.org

Annese V. Genetics and Epigenetics of IBD. Pharmacol. Res. 2020;159:104892. doi: 10.1016/j. phrs.2020.104892.

Turner D., Ruemmele F. M., Orlanski-Meyer E., Griffiths A., De Capri J. M. et al. Management of paediatric ulcerative colitis. Part 1: ambulatory care – an evidence-based Guideline from European Crohn s and Colitis Organizationa and European Society pf Paediatric Gastroenterology, Hepatology and Nutrition. JPGH August 2018, nr. 2; 67: 257-291. www.jpgn.org.

Turner D., Ruemmele F. M., Orlanski-Meyer E., Griffiths A., De Capri J. M. et al. Management of paediatric ulcerative colitis. Part 2: acute severe colitis - an evidence-based Guideline from European Crohn s and Colitis Organizationa and European Society pf Paediatric Gastroenterology, Hepatology and Nutrition. JPGH August 2018, nr. 2; 67: 292-310. www.jpgn.org.

Sykora J., Pomahacova R., Kreslova M. Et al. Current global trends in the incidence of pediatric – onset in inflammatory bowel disese. World J Gastroenterol., 2018, Jul 7; 24(25): 2741-2763. doi: 10.3748/wjg.v24. i25.2741.

Ashton J. J., Beattie R. M. Inflamatory bowel disease: recent developments. Department of Paediatric Gastroenterology, Southampton Children’s Hospital, Southampton, UK. Arch Dis Child, 2024, v. 109(5): 370-376. DOI: 10.1136/archdischild-2023-325668.

Feng J. S., Ye Y., Guo C. G. et al. Ulcerative colititis with inflammatory polyposis in a teenage boy: a case report. World J gastroenterol. 2015, Jan 21; 21(3):1044-1048. doi: 10.3748/wjg.v21.i3.1044.

Published

2026-03-26

Issue

Section

Research Article

Categories