Pulmonary embolism in postmenopausal women: a case report

Authors

  • Doina RANGA Nicolae Testemițanu State University of Medicine and Pharmacy
  • Svetlana SHVETS Municipal Clinical Hospital "Holy Trinity"
  • Andrei CEALAN Nicolae Testemițanu State University of Medicine and Pharmacy; Municipal Clinical Hospital "Holy Trinity"
  • Sergiu MATCOVSCHI Nicolae Testemițanu State University of Medicine and Pharmacy
  • Ion SIRBU Nicolae Testemițanu State University of Medicine and Pharmacy
  • Hristiana CAPROSH IP Universitatea de Medicină și Farmacie ”Nicolae Testemițanu”
  • Cornelia TALMACI Nicolae Testemițanu State University of Medicine and Pharmacy
  • Natalia CAPROSH Nicolae Testemițanu State University of Medicine and Pharmacy

DOI:

https://doi.org/10.52692/1857-0011.2024.3-80.39

Keywords:

Pulmonary thromboembolism, women

Abstract

This study presents the case of a 73-year-old female patient with multiple cardiovascular comorbidities. The case’s particularities include nonspecific symptoms, delayed presentation, and a dramatic outcome despite the implementation of complex treatment, including anticoagulation. The literature review focused on the following aspects: the incidence and severity of PE in women versus men, the role of comorbidities in influencing PE risk, and differences in thrombolysis usage.

Author Biographies

Doina RANGA , Nicolae Testemițanu State University of Medicine and Pharmacy

PhD student, 2nd year

Svetlana SHVETS, Municipal Clinical Hospital "Holy Trinity"

physician, pulmonology department

Andrei CEALAN , Nicolae Testemițanu State University of Medicine and Pharmacy; Municipal Clinical Hospital "Holy Trinity"

imaging specialist, univ. assistant

Sergiu MATCOVSCHI, Nicolae Testemițanu State University of Medicine and Pharmacy

hab. MD, univ. prof.

Ion SIRBU , Nicolae Testemițanu State University of Medicine and Pharmacy

univ. assistant

Hristiana CAPROSH, IP Universitatea de Medicină și Farmacie ”Nicolae Testemițanu”

PhD med. sci., univ. assoc. prof.

Cornelia TALMACI , Nicolae Testemițanu State University of Medicine and Pharmacy

PhD med. sci., univ. assoc. prof.

Natalia CAPROSH , Nicolae Testemițanu State University of Medicine and Pharmacy

hab. MD, univ. prof.

References

Robert-Ebadi H, Le Gal G, Carrier M, et al. Differences in clinical presentation of pulmonary embolism in women and men. J Thromb Haemost. 2010 Apr;8(4):693-8.

Ramos, A., Flores M., Benzant I. et al. Pulmonary embolism in Spain: Differences between men and women. European Respiratory Journal. 2015; 20(1):546.

Tanabe Y., Yamamoto T., Murata T. et al. Gender Differences Among Patients With Acute Pulmonary Embolism. Am J Cardiol. 2018 Sep 15;122(6):1079- 1084.

Yoshikawa Y, Yamashita Y, Morimoto T. et al. COMMAND VTE Registry Investigators. Sex Differences in Clinical Characteristics and Outcomes of Patients With Venous Thromboembolism - From the COMMAND VTE Registry. Circ J. 2019 Jun 25;83(7):1581-1589.

Ciarambino, T.; Crispino, P.; Para, O.; Giordano, M. Gender Medicine: A New Possible Frontiers of Venous Thromboembolism. Stresses. 2023, 3, 167-181.

Keller K., Rappold L., Gerhold-Ay A. et al. Sex- specific differences in pulmonary embolism. Thromb Res. 2019 Jun;178:173-181.

de Moreuil C, Le Mao R, Le Moigne E. et al. Long-term recurrence risk after a first venous thromboembolism in men and women under 50 years old: A French prospective cohort. Eur J Intern Med. 2021 Feb;84:24- 31.

Pribish AM, Beyer SE, Krawisz AK., et al. Sex differences in presentation, management, and outcomes among patients hospitalized with acute pulmonary embolism. Vasc Med. 2020 Dec;25(6):541-548.

Giustozzi M, Valerio L, Agnelli G, et al. Sex-specific differences in the presentation, clinical course, and quality of life of patients with acute venous thromboembolism according to baseline risk factors. Insights from the PREFER in VTE. Eur J Intern Med. 2021 Jun;88:43-51.

Tian H, Zhang Y, Liu J, et al. CURES investigators. Sex disparities of clinical manifestations in acute pulmonary embolism and predictive value for in- hospital mortality: Insights from CURES. Thromb Res. 2024 Nov;243:109146.

Newman J, Bruno E, Allen S, et al. The influence of patient sex on pulmonary embolism evaluation, treatment modality, and outcomes. Vasc Med. 2024 Sep 12:1358863X241281872.

Published

2025-09-09

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Section

Research Article

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