REVIEW of the monograph “RELAPSE OF TUBERCULOSIS”

Abstract

The monograph “Relapse of Tuberculosis” is a scientific work distinguished by its relevance and major importance. The author addresses one of the most pressing issues faced by public health. Tuberculosis relapse is characterized by its impact on the epidemiological situation, which is already reflected in the first chapter of the work. The monograph is structured into 5 chapters, presenting the most significant aspects of tuberculosis relapse. Considering the subject, the work consistently highlights the risk factors for developing relapse. Understanding their complexity and implications will contribute to the development of appropriate actions and strategies to counter the negative impact of relapse on healthy individuals. This monograph is not only a source of knowledge but also an important guide, providing updated and relevant information for a deeper understanding of the role of immunological and genetic mechanisms in the development of tuberculosis relapse. In this regard, the work describes the responses of natural resistance and acquired immunity to Mycobacterium tuberculosis, including the immune particularities in relapse. The main genetic aspects detailed include the genetic basis for susceptibility to tuberculosis, genetic control of tuberculosis infection and disease, innate human immunogenetics, and mycobacterial susceptibility. Factors influencing the functions of innate immunity gene polymorphisms are elucidated. The author presents current progress in studying polymorphisms associated with susceptibility/resistance to tuberculosis, including studies conducted on the local population and at the genome level, which provide important evidence for the role of the genetic factor in tuberculosis development, with heterogeneous effects depending on population, clinical phenotypes, and epidemiological situation. This scientific-practical work provides relevant and up-to-date information, with coherently structured topics. It is an important contribution, fostering a deeper understanding of the complexity of tuberculosis relapse. The presence of extensive factual material, skillful use of national and international data, as well as critical and multi-perspective reflections on the issue are noted. The author demonstrates high competence by using a representative, extensive, and recent bibliography, proving a solid knowledge of the research subject. The text is clearly written, with rigorous and convincing presentation, reflecting the author’s professionalism and remarkable scientific preparation. The monograph is of special scientific and practical interest and can serve as a reference for specialists, academics, residents, and students. Thus, the subject is highly relevant, both theoretically and practically, and opens new directions for scientific research.