Phagocytosis in pulmonary tuberculosis associated with COVID-19 infection.
DOI:
https://doi.org/10.52692/1857-0011.2025.3-83.09Keywords:
pulmonary tuberculosis, COVID-19, immunology, phagocytosis, acid and alkaline phosphataseAbstract
In the context of the persistence of the pandemic caused by the new coronavirus infection, it becomes essential to study the impact of COVID-19 infection on the evolution of pulmonary tuberculosis (TB) when the two pathologies coexist. The aim of the research was to study the characteristics of indises of phagocytosis and microbicidal activity of phagocytes in patients with COVID-19-associated pulmonary TB. The study included 42 patients: a) research group – 21 patients with pulmonary TB and COVID-19, b) control group – 21 patients with pulmonary TB. In these patients, the functional activity of neutrophils used NBT test, phagocytic index (PI) and phagocytic number (PN), as well as the activity of acid and alkaline phosphatase were evaluated. Changes in the functional-metabolic activity of neutrophil granulocytes in patients with COVID-19associated pulmonary TB were due to reduced acid and alkaline phosphatase activity, NBT test parameters, PN and PI. The reduction of these parameters in segmented neutrophils may be a marker of viral superinfection, such as COVID-19 infection.
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