Distribution of rs6795970 SNP variants in SCN10A gene in young population of the Republic of Moldova.

Rezumat

Background. PR interval reflects atrial and atrioventricular nodal conduction time and is an important determinant of arrhythmia risk. Genome-wide association studies (GWAS) have identified association of nonsynonymous SNP, rs6795970, in the SCN10A gene with PR interval in individuals of European ancestry. Purpose. To estimate the distribution of rs6795970 variants, associated with PR interval in young population of Republic of Moldova. Methods. 1390 young participants from Republic of Moldova with age range: 19-25 years, were genotyped for rs6795970 in the SCN10A gene, using TaqMan technology. Results. The genotype A/A, A/G, G/G distributions of rs6795970 among the young participants were 15%, 48%, 37% respectively (χ2 = 0.161, p = 0.688). The allele frequencies for A and G in young participants were 39% and 61% respectively. Conclusion. The minor allele frequency (MAF) in young Moldavian population was 0.39 for rs679570 and was consistent with 1000 Genomes Project data in the European population – 0.41. 15% of all participants (the AA genotype), may have an increased risk of conduction abnormalities.