VARIAȚIILE CIRCADIENE A NEUROTRANSMIȚĂTORILOR ȘI TULBURĂRILE COGNITIVE
DOI:
https://doi.org/10.52692/1857-0011.2023.3-77.47Cuvinte cheie:
ritm circadian, neurotransmițători, funcții cognitive, boli neurodegenerativeRezumat
Pentru a anticipa și a se adapta la evenimentele zilnice recurente determinate de rotația pământului, organismele prezintă mecanisme de reglare menite să controleze homeostazia în diferite condiții de iluminare, numite ritm circadian (RC). RC reprezintă o rețea biologică endogenă responsabilă de coordonarea ciclurilor timp de 24 de ore la nivel genetic, biochimic, fiziologic și comportamental. Sistemele de control ale RC transmit semnale ale timpului în întregul organism, toate procesele interne prezentând un nivel de activitate diurn maxim și minim gestionat prin intermediul modulării neurotransmisiei în structurile neuronale cheie.Cunoașterea variaţiilor cotidiene ale activității neurotransmițătorilor în sistemul nervos central este esențială în stabilirea mecanismelor eficiente de neuroprotecție. Acest studiu sintetizează cunoștințele actuale privind interacțiunea dintre ritm circadian, fluctuații ale neurotransmițătorilor, precum și impactul acestora asupra neuroprotecției și sănătății mintale.
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