Molecular genetic characteristics of Mycobacterium tuberculosis strains isolated from newly identified tuberculosis patients in the Republic of Azerbaijan.
DOI:
https://doi.org/10.52692/1857-0011.2024.2-79.04Cuvinte cheie:
Tuberculoză drogrezistentă, „TB-TEST”, metodă molecular geneticăRezumat
În scopul diagnosticării precoce a tuberculozei rezistente la medicamente, 198 de probe de sputa obținute de la pacienți primari cu diferite forme clinice de tuberculoză pulmonară au fost examinate folosind metoda genetică moleculară, setul TB-TEST. Utilizarea unei metode genetice moleculare pentru determinarea sensibilității la medicament a agentului patogen al tuberculozei, care are sensibilitate și specificitate ridicate, accelerează semnificativ diagnosticul, permițând pacientului să i se prescrie un regim de tratament rațional în 2-3 zile de la internarea în clinică. Metoda oferă identificarea simultană a mutațiilor în genele rpoB, katG, inhA, ahpC, embB, rrs, eis, gyrA, gyrВ și, de asemenea, determină principalele genotipuri semnificative clinic ale M. tuberculosis, ceea ce face posibilă corectarea în timp util a tratamentului specific.
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