UTILIZAREA CRITERIILOR PENTRU TROMBOZELE INTRACEREBRALE POST- COVID-19: SERIE DE CAZURI
DOI:
https://doi.org/10.52692/1857-0011.2024.3-80.21Cuvinte cheie:
Tromboza venoasă cerebrală, COVID-19, criterii de diagnostic, anticoagulanteRezumat
Diagnosticul trombozei venoase cerebrale (TVC) post-COVID-19 la maturi se efectuează conform criteriilor: (1) vârsta ≥18 ani; (2) TVC confirmată imagistic sau la autopsie; (3) COVID-19 confirmat prin test PCR cu 90 zile înainte de diagnosticare TVC sau în timpul internării.Scopul lucrării: Analiza utilității criteriilor de diagnostic pentru stabilirea diagnosticului de tromboză cerebrală post- COVID-19. Material și Metode: Au fost evaluate cazurile tuturor pacienților suspecți de TVC, internați în Institutul de Neurologie și Neurochirurgie „Diomid Gherman” în anii 2020 - 2023. A fost analizată aplicarea criteriilor diagnostice. Rezultate și discuții: Au fost identificați 5 pacienți cu vârsta 30-66 ani, diagnosticați cu TVC post-COVID-19 confirmat prin test PCR. Acuze prezentate la internare au fost: cefalee severă instalată brusc, diplopie, dureri retroorbitale, exoftalm, ataxie. Investigații efectuate au fost: angio-tomografie computerizată (CT), imagistică prin rezonanță magnetică (IRM) cerebrală cu contrast, angiografie cu substracţie digitală a capului, angiografie clasică. TVC a fost determinată la nivelul sinusului transvers și cavernos. Timpul mediu de la confirmarea COVID-19 la debut TVC a fost 93 zile. Dintre acești pacienți, unul a prezentat AVC de tip ischemic cu transformare hemoragică în sistemul vertebro-bazilar, utilizator de contraceptive orale, în antecedente cu migrenă cu aură; altul a prezentat meningită secundară bacteriană. A fost inițiat tratament anticoagulant, unor pacienți suplimentar antibiotice. Concluzii. Tromboza venoasă cerebrală trebuie suspectată în cazurile tuturor pacienților post-COVID-19. Utilizarea criteriilor de diagnostic poate facilita diagnosticul precoce și abordarea terapeutică promptă și corectă a pacienților.
Referințe
Gameiro J, Ferro JM, Canhao P, Stam J, Barinagarrementeria F, Lindgren A, et al. Prognosis of cerebral vein thrombosis presenting as isolated headache: early vs. late diagnosis. Cephalalgia: Int J Headache 2012;32(5):407-412
Bousser MG, Chiras J, Bories J, Castaigne P. Cerebral venous thrombosis a review of 38 cases. Stroke 1985; 16: 199–213
Einhanupl KM, Villringer A, Haberl RL et al. Clinical spectrum of sinus venous thrombosis. In: EinhaÅN upl K, Kempski O, Baethmann A, eds. Cerebral Sinus Thrombosis. Experimental and Clinical Aspects. New York: Plenum Press, 1990: 149–155
deVeber G, Andrew M, Adams C for the Canadian Pediatric Ischemic Stroke Study Group. Cerebral sinovenous thrombosis in children. New England Journal of Medicine 2001; 345: 417–23
De Bruijn SFTM, de Haan RJ, Stam J for the Cerebral Venous Sinus Thrombosis Study Group. Clinical features and prognostic factors of cerebral venous and sinus thrombosis in a prospective series of 59 patients. Journal of Neurology, Neurosurgery and Psychiatry 2001; 70: 105–8
Cavalcanti DD, Raz E, Shapiro M, Dehkharghani S, Yaghi S, Lillemoe K, et al. Cerebral venous thrombosis associated with COVID-19. Am J Neuroradiol. (2020) 41:1370–6. doi: 10.3174/ajnr.A6644
Abdalkader M, Shaikh SP, Siegler JE, Cervantes- Arslanian AM, Tiu C, Radu RA, et al. Cerebral Venous Sinus Thrombosis in COVID-19 Patients: A Multicenter Study and Review of Literature. J Stroke Cerebrovascular Dis. (2021) 4:105733. doi: 10.1016/j. jstrokecerebrovasdis.2021.105733
Al-Mufti F, Amuluru K, Sahni R, Bekelis K, Karimi R, Ogulnick J, et al. Cerebral venous thrombosis in COVID-19: A New York Metropolitan Cohort Study. Am J Neuroradiol. (2021) 42:1196–200. doi: 10.3174/ ajnr.A7134
Dakay K, Cooper J, Bloomfield J, Overby P, Mayer SA, Nuoman R, et al. Cerebral venous sinus thrombosis in COVID-19 infection: a case series and review of the literature. J Stroke Cerebrovascular Dis. (2020) 6:105434. doi: 10.1016/j. jstrokecerebrovasdis.2020.105434
Cheng Q, Yang Y, Gao J. Infectivity of human coronavirus in the brain. EBioMedicine. (2020) 56:102799. doi: 10.1016/j.ebiom.2020. 102799
Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host–virus interaction, and proposed neurotropic mechanisms. ACS Chem Neurosci. (2020) 11:995– 8. doi: 10.1021/acschemneuro.0c00122
Meinhardt J, Radke J, Dittmayer C, Franz J, Thomas C, Mothes R, et al. Olfactory transmucosal SARS- CoV-2 invasion as a port of central nervous system entry in individuals with COVID19. Nat Neurosci. (2021) 24:168–75. doi: 10.1038/s41593-020-00 758-5
Canhao P, Ferro JM, Lindgren AG, et al; ISCVT Investigators. Causes and predictors of death in cerebral venous thrombosis. Stroke 2005;36:1720–25
Girot M, Ferro JM, Canhao P, et al; ISCVT Investigators. Predictors of outcome in patients with cerebral venous thrombosis and intracerebral hemorrhage. Stroke 2007;38:337–42
Ferro JM, Canha˜o P, Stam J, Bousser MG, Barinagarrementeria F for the ISCVT Investigators. Prognosis of cerebral vein and dural sinus thrombosis. Results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke 2004; 35: 664–70
De Bruijn SFTM, Stam J, Kapelle LJ for the Cerebral Venous Sinus Thrombosis Study Group. Thunderclap headache as first symptom of cerebral venous sinus thrombosis. Lancet 1996; 348: 1623– 25
Porfidia A, Pola R. Venous thromboembolism in COVID19 patients. J Thromb Haemost: JTH 2020
Poillon G, Obadia M, Perrin M, Savatovsky J, Lecler Cerebral venous thrombosis associated with COVID-19 infection: causality or coincidence? J Neuroradiol. 2020
Sensitivity and Specificity of SARS-CoV-2 Rapid Antigen Detection Tests Using Oral, Anterior Nasal, and Nasopharyngeal Swabs: a Diagnostic Accuracy Study, American Society for Microbiology, February 2, 2022, https://doi.org/10.1128/spectrum.02029-21
Masuhr F, Mehraein S, EinhaÅN upl K. Cerebral venous and sinus thrombosis. Journal of Neurology 2004; 251: 11–23
Bousser MG. Cerebral venous thrombosis. Nothing, heparin, or local thrombolysis? Stroke 1999; 30: 481–3
Lechien JR, Chiesa-Estomba CM, Place S, Van Laethem Y, Cabaraux P, Mat Q, et al. Clinical and epidemiological characteristics of 1420 European patients with mild-tomoderate coronavirus disease 2019. J Intern Med. 2020;288(3):335-344
Li Y, Li M, Wang M, Zhou Y, Chang J, Xian Y, et al. Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study. Stroke Vasc Neurol 2020
Carfi A, Bernabei R, Landi F, Gemelli Against C-P- ACSG. Persistent symptoms in patients after acute COVID-19. JAMA 2020
Baldini T, Asioli GM, Romoli M, Carvalho Dias M, Schulte EC, Hauer L, et al. Cerebral venous thrombosis and severe acute respiratory syndrome coronavirus-2 infection: A systematic review and meta-analysis. Eur J Neurol. (2021) 28:3478–90. doi: 10.1111/ene.14727
Abouhashem S, Eldawoody H, Taha MM. Cerebral venous sinus thrombosis in patients with COVID-19 infection. Interdisciplinary Neurosurgery. (2021) 24:101091. doi: 10.1016/j.inat.2021.101091
Ageno W, Beyer-Westendorf J, Garcia DA, Lazo- Langner A, McBane RD, Paciaroni M. Guidance for the management of venous thrombosis in unusual sites. J Thromb Thrombolysis. (2016) 41:129–43. doi: 10.1007/s11239-015-1308-1
Lodigiani C, Iapichino G, Carenzo L, Cecconi M, Ferrazzi P, Sebastian T, et al. Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thromb Res. (2020) 191:9–14. doi: 10.1016/j. thromres.2020.04.024
GHIDUL ACADEMIEI Americane de neurologie pe Diagnostic și management in tromboza venoasa cerebrala
Ghidul practic pe sinus tromboza
Severe Acute RespiratorySyndromeCoronavirus 2 Infectionand Ischemic Stroke- Eduard ValdesValderrama, MD
KelleyHumbert, MD; Aaron Lord, MD; Jennifer Frontera, MD; ShadiYaghi , MD
Abou-Ismail MY, Diamond A, Kapoor S, Arafah Y, Nayak L. The hypercoagulable state in COVID-19: incidence, pathophysiology, and management. Thromb Res 2020;194:101-115
Cohoon KP, Mahe G, Tafur AJ, Spyropoulos AC. Emergence of institutional antithrombotic protocols for coronavirus 2019. Res Pract Thromb Haemost. 2020;4(4):510- 517
Spyropoulos AC, Lipardi C, Xu J, Peluso C, Spiro TE, De Sanctis Y, et al. Modified IMPROVE VTE risk score and elevated D-Dimer identify a high venous thromboembolism risk in Acutely Ill medical population for extended thromboprophylaxis. TH Open 2020;4(1):e59-e65
Poyiadji N, Shahin G, Noujaim D, Stone M, Patel S, Griffith B. COVID-19-associated acute hemorrhagic necrotizing encephalopathy: CT and MRI features. Radiology 2020:201187
Dogra S, Jain R, Cao M, Bilaloglu S, Zagzag D, Hochman S, et al. Hemorrhagic stroke and anticoagulation in COVID-19. J Stroke Cerebrovasc Dis 2020;29(8):104984.
Anipindi M, Scott A, Joyce L, Wali S, Morginstin M. Case Report: Cerebral Venous Sinus Thrombosis and COVID-19 Infection. Front Med (Lausanne). 2021 Oct 15;8:741594. doi: 10.3389/fmed.2021.741594. PMID: 34722579; PMCID: PMC8554241
Cavalcanti DD, Raz E, Shapiro M, Dehkharghani S, Yaghi S, Lillemoe K, Nossek E, Torres J, Jain R, Riina HA, Radmanesh A, Nelson PK. Cerebral Venous Thrombosis Associated with COVID-19. AJNR Am J Neuroradiol. 2020 Aug;41(8):1370-1376. doi: 10.3174/ajnr.A6644. Epub 2020 Jun 18. PMID: 32554424; PMCID: PMC7658892
Nwajei F, Anand P, Abdalkader M, Andreu Arasa VC, Aparicio HJ, Behbahani S, Curiale G, Daneshmand A, Dasenbrock H, Mayo T, Mian A, Nguyen T, Ong C, Romero JR, Sakai O, Takahashi C, Cervantes- Arslanian AM. Cerebral Venous Sinus Thromboses in Patients with SARS-CoV-2 Infection: Three Cases and a Review of the Literature. J Stroke Cerebrovasc Dis. 2020 Dec;29(12):105412. doi: 10.1016/j.jstrokecerebrovasdis.2020.105412. Epub 2020 Oct 19. PMID: 33254367; PMCID: PMC7571902
Takasu S, Ariizumi M, Matsumoto S, Nakagawa H, Iwadate K. Cerebral venous sinus thrombosis associated with COVID-19: an autopsy case report. Forensic Sci Med Pathol. 2022 Mar;18(1):80-85. doi: 10.1007/s12024-022-00458-5. Epub 2022 Jan 24. PMID: 35067810; PMCID: PMC8784249
Panichpisal K, Ruff I, Singh M, Hamidi M, Salinas PD, Swanson K, Medlin S, Dandapat S, Tepp P, Kuchinsky G, Pesch A, Wolfe T. Cerebral Venous Sinus Thrombosis Associated With Coronavirus Disease 2019: Case Report and Review of the Literature. Neurologist. 2022 Sep 1;27(5):253-262. doi: 10.1097/ NRL.0000000000000390. PMID: 34855659; PMCID: PMC9439631
B.F. Kurt, K.U. Erman, O. Güven, O. Kas¸ikeman, A rare effect of covid-19: cerebral venous sinus thrombosis case presentation, Journal of Emergency Medicine Case Reports 12 (3) (2021) 91–93
I. Kaur, C. Vyas, M. Mughal, H. Gandhi, D. Du, Cerebral venous sinus thrombosis in COVID-19: an unusual presentation, Cureus 13 (3) (2021) 1–3
V.R. Ostovan, R. Foroughi, M. Rostami, M. Almasi- Dooghaee, M. Esmaili, A. A. Bidaki, et al., Cerebral venous sinus thrombosis associated with COVID-19: a case series and literature review, J. Neurol. 1 (1) (2021) 1–12
A.Q. Qader, O. Nahzat, A.J. Qader, S. Atahi, A case report of cerebral venous infarction due to venous sinus thrombosis as complication in a Covid-19 patient, Radiology Case Reports 16 (11) (2021) 3336–3340.
Descărcări
Publicat
Număr
Secțiune
##category.category##
Licență
Copyright (c) 2025 Buletinul Academiei de Științe a Moldovei. Științe medicale
Această lucrare este licențiată în temeiul Creative Commons Attribution 4.0 International License.
