Роль генетического фактора в развитии рецидива туберкулеза

Авторы

  • Елена ТУДОР Институт пульмунологии им. Кирилла Драганюка

DOI:

https://doi.org/10.52692/1857-0011.2024.3-80.34

Ключевые слова:

туберкулез, рецидив, генетический фактор, полиморфизм

Аннотация

Туберкулез остается глобальной проблемой для здоровья, со значительными показателями смертности по всему миру. В обзоре литературы рассматривается современный прогресс в изучении полиморфизмов, связанных с восприимчивостью к туберкулезу, включая полногеномные исследования. Также рассматривается вопрос о том, как эти результаты соотносятся с генетическими полиморфизмами, связанными с устойчивостью к развитию туберкулеза. Несмотря на достигнутый прогресс, данных о роли генетического фактора в развитии рецидива туберкулеза недостаточно, что подчеркивает необходимость дополнительных исследований.

Биография автора

Елена ТУДОР, Институт пульмунологии им. Кирилла Драганюка

д-р мед. н., ст. н. сотр., чл.-кор. АНМ

Библиографические ссылки

Houben RM, Dodd PJ. The global burden of latent tuberculosis infection: a re-estimation using mathematical modelling. PLoS Med. 2016;13(10):e1002152.

Puffer R. Familial susceptibility to tuberculosis; its importance as a public health problem. p. 106 Cambridge, MA: 1944. Harvard University Press.

Möller M, Hoal EG. Current findings, challenges and novel approaches in human genetic susceptibility to tuberculosis. Tuberculosis. 2010 Mar;90(2):71-83.

WHO. Global Tuberculosis Report 2021. World Health Organization. 2021, 265 p.

Möller M, Hoal EG. Current findings, challenges and novel approaches in human genetic susceptibility to tuberculosis. Tuberculosis. 2010 Mar;90(2):71-83.

Daya M, van der Merwe L, Gignoux CR, van Helden PD, Möller M, Hoal EG. Using multi-way admixture mapping to elucidate TB susceptibility in the South African Coloured population. BMC Genomics. 2014. 15:1021.

Du J, Li Q, Liu M, Wang Y, Xue Z, Huo F, Zhang X, et al. Distinguishing Relapse From Reinfection With Whole-Genome Sequencing in Recurrent Pulmonary Tuberculosis: A Retrospective Cohort Study in Beijing, China. Front Microbiol. 2021 Dec 8;12:754352.

Daya M, van der Merwe L, van Helden PD, Möller M, Hoal EG. The role of ancestry in TB susceptibility of an admixed South African population. Tuberculosis. 2014. 94: 413–420.

Aravindan PP. Host genetics and tuberculosis: Theory of genetic polymorphism and tuberculosis. Lung India. 2019 May-Jun;36(3):244-252.

Torrelles JB, Azad AK, Schlesinger LS. Fine discrimination in the recognition of individual species of phosphatidyl-myo-inositol mannosides from Mycobacterium tuberculosis by C-type lectin pattern recognition receptors. J Immunol. 2006 Aug 1;177(3):1805-16.

East L, Isacke C. The mannose receptor family. Biochim Biophys Acta. 2002;1572:364–86.

Beharka AA, Crowther JE, McCormack FX. et al. Pulmonary surfactant protein A activates a phosphatidylinositol 3-kinase/calcium signal transduction pathway in human macrophages: participation in the up-regulation of mannose receptor activity. J Immunol. 2005;175:2227–36.

Kang PB, Azad AK, Torrelles JB. et al. The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis. J Exp Med. 2005;202:987–99.

Zhang X, Jiang F, Wei L, Li F, Liu J, Wang C, Zhao M, Jiang T, Xu D, Fan D, Sun X, Li JC. Polymorphic allele of human MRC1 confer protection against tuberculosis in a Chinese population. Int J Biol Sci. 2012;8(3):375-82.

van Kooyk Y. C-type lectins on dendritic cells: key modulators for the induction of immune responses. Biochem Soc Trans. 2008 Dec;36(Pt 6):1478-81.

Tailleux L, Pham-Thi N, Bergeron-Lafaurie A, et al. DC-SIGN induction in alveolar macrophages defines privileged target host cells for mycobacteria in patients with tuberculosis. PLoS Med. 2005 Dec;2(12):e381.

Vannberg FO, Chapman SJ, Khor CC., et al. CD209 genetic polymorphism and tuberculosis disease. PLoS One. 2008 Jan 2;3(1):e1388.

Barreiro LB, Neyrolles O, Babb CL, Tailleux L, et al. Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis. PLoS Med. 2006 Feb;3(2):e20.

Gómez LM, Anaya JM, Sierra-Filardi E, Cadena J, Corbí A, Martín J. Analysis of DC-SIGN (CD209) functional variants in patients with tuberculosis. Hum Immunol. 2006 Oct;67(10):808-11.

Zheng R, Zhou Y, Qin L, Jin R, et al. Relationship between polymorphism of DC-SIGN (CD209) gene and the susceptibility to pulmonary tuberculosis in an eastern Chinese population. Hum Immunol. 2011 Feb;72(2):183-6.

Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol. 2010 May;11(5):373-84.

Rosenberg PS, Che A, Chen BE. Multiple hypothesis testing strategies for genetic case-control association studies. Stat Med. 2006 Sep 30;25(18):3134-49.

Heldwein KA, Fenton MJ. The role of Toll-like receptors in immunity against mycobacterial infection. Microbes Infect. 2002 Jul;4(9):937-44.

Jo EK, Yang CS, Choi CH, Harding CV. Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll- like receptors. Cell Microbiol. 2007 May;9(5):1087-98.

Vu A, Calzadilla A, Gidfar S, Calderon-Candelario R, Mirsaeidi M. Toll-like receptors in mycobacterial infection. Eur J Pharmacol. 2017 Aug 5;808:1-7.

Kim JS, Kim YR, Yang CS. Latest Comprehensive Knowledge of the Crosstalk between TLR Signaling and Mycobacteria and the Antigens Driving the Process. J Microbiol Biotechnol. 2019 Oct 28;29(10):1506-1521.

Thada S, Horvath GL, Müller MM, Dittrich N, et al. Interaction of TLR4 and TLR8 in the Innate Immune Response against Mycobacterium Tuberculosis. Int J Mol Sci. 2021 Feb 4;22(4):1560.

Salie M, Daya M, Lucas LA et al. Association of toll-like receptors with susceptibility to tuberculosis suggests sex-specific effects of TLR8 polymorphisms. Infect Genet Evol 2015: 34: 221–229.

Bukhari M, Aslam MA, Khan A., et al. TLR8 gene polymorphism and association in bacterial load in southern Punjab of Pakistan: an association study with pulmonary tuberculosis. Int J Immunogenet 2015: 42: 46–51.

Varzari A, Deyneko IV, Vladei I, Grallert H, Schieck M, Tudor E, Illig T. Genetic variation in TLR pathway and the risk of pulmonary tuberculosis in a Moldavian population. Infect Genet Evol. 2019 Mar;68:84-90.

Dalgic N, Tekin D, Kayaalti Z, Soylemezoglu T, et al. Arg753Gln polymorphism of the human Toll-like receptor 2 gene from infection to disease in pediatric tuberculosis. Hum Immunol. 2011 May;72(5):440-5.

Thuong NT, Hawn TR, Thwaites GE, et al. A polymorphism in human TLR2 is associated with increased susceptibility to tuberculous meningitis. Genes Immun. 2007 Jul;8(5):422-8.

Varzari A., Suruceanu I., Axentii E., Corloteanu A., Vladei I., Tudor E. Analiza asocierii polimorfismelor TLR2 (-196 până la -174 ins / del) și TLR9 (1174 C / T) cu tuberculoza pulmonară în populația Moldovei. Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţe Medicale, 2019, nr. 3(63), pp. 112-115. ISSN 1857-0011.

Varzari A., Tudor E., Suruchanu I., Vladei I., Korlotyanu A., A., Аksentiy E., Illig T. Association of gene TRL2 polymorphism with pulmonary tuberculosis in the population of Moldova. Tuberculosis and Lung Diseases, 2018, nr. 6(96), p. 65.

Velez DR, Wejse C, Stryjewski ME, et al. Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans. Hum Genet. 2010 Jan;127(1):65-73.

Mhmoud NA. Association of Toll-like Receptors 1, 2, 4, 6, 8, 9 and 10 Genes Polymorphisms and Susceptibility to Pulmonary Tuberculosis in Sudanese Patients. Immunotargets Ther. 2023 Apr 6;12:47-75.

Varshney D, Singh S, Sinha E, Mohanty KK, Kumar S, Kumar Barik S, Patil SA, Katara P. Systematic review and meta-analysis of human Toll-like receptors genetic polymorphisms for susceptibility to tuberculosis infection. Cytokine. 2022 Apr;152:155791.

Dittrich N, Berrocal-Almanza LC, Thada S, Goyal S, et al. Toll-like receptor 1 variations influence susceptibility and immune response to Mycobacterium tuberculosis. Tuberculosis. 2015 May;95(3):328-35.

Xue X., Qiu Y., Jiang D., Jin T., et al. The association analysis of TLR2 and TLR4 gene with tuberculosis in the Tibetan Chinese population. Oncotarget. 2017; 8: 113082-113089

Jin X, Yin S, Zhang Y, Chen X. Association between TLR2 Arg677Trp polymorphism and tuberculosis susceptibility: A meta-analysis. Microb Pathog. 2020 Jul;144:104173.

Meyer CG, Reiling N, Ehmen C, et al. TLR1 Variant H305L Associated with Protection from Pulmonary Tuberculosis. PLoS One. 2016 May 23;11(5):e0156046

Zhang M, Chen G, He JQ. Variants of Toll-like receptor 6 associated with tuberculosis susceptibility in the Chinese Tibetan population. Microb Pathog. 2022 Jan;162:105208.

Zhang Y, Jiang T, Yang X, Xue Y, et al. Toll-like receptor -1, -2, and -6 polymorphisms and pulmonary tuberculosis susceptibility: a systematic review and meta-analysis. PLoS One. 2013 May 14;8(5):e63357.

Varzari A, Deyneko IV, Tudor E, Grallert H, Illig T. Synergistic effect of genetic polymorphisms in TLR6 and TLR10 genes on the risk of pulmonary tuberculosis in a Moldavian population. Innate Immun. 2021 Jul;27(5):365-376.

Lai YF, et al. Functional polymorphisms of the TLR7 and TLR8 genes contribute to Mycobacterium tuberculosis infection. Tuberculosis. 2016;98:125–31.

Rosenberg PS, Che A, Chen BE. Multiple hypothesis testing strategies for genetic case-control association studies. Stat Med. 2006 Sep 30;25(18):3134-49.

Khor CC, Chapman SJ, Vannberg FO, et al. A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nat Genet. 2007 Apr;39(4):523-8.

Hawn TR, Dunstan SJ, Thwaites GE, et al. A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis. J Infect Dis. 2006 Oct 15;194(8):1127-1134.

Zhang YX, Xue Y, Liu JY, Zhao MY, et al. Association of TIRAP (MAL) gene polymorhisms with susceptibility to tuberculosis in a Chinese population. Genet Mol Res. 2011 Jan 4;10(1):7-15.

Baeke F, Korf H, Overbergh L, van Etten E, et al. Human T lymphocytes are direct targets of 1,25-dihydroxy1,25(OH)2D3 in the immune system. J Steroid Biochem Mol Biol. (2010) 121:221–7.

Lee YH, Song GG. Vitamin D receptor gene FokI, TaqI, BsmI, and ApaI polymorphisms and susceptibility to pulmonary tuberculosis: a meta-analysis. Genet Mol Res. (2015) 14:9118–29.

Selvaraj P, Chandra G, Kurian SM, Reetha AM, Narayanan P. R. Association of vitaminD receptor gene variants of Bsm, I, ApaI and FokI polymorphisms with susceptibility or resistance to pulmonary tuberculosis. Curr Sci. (2003) 84:1564–8.

Zhao Y, Bu H, Hong K, Yin H, Zou YL, et al. Genetic polymorphisms of CCL1 rs2072069 G/A and TLR2 rs3804099 T/C in pulmonary or meningeal tuberculosis patients. Int J Clin Exp Pathol.(2015) 8:12608–20.

Wilkinson RJ, Llewelyn M, Toossi Z, Patel P, et al. Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case-control study. Lancet (2000) 355:618–21.

Bellamy R, Ruwende C, Corrah T, McAdam KP, et al. Tuberculosis and chronic hepatitis B virus infection in Africans and variation in the vitamin D receptor gene. J Infect Dis. (1999) 179:721–24.

Rashedi J, Asgharzadeh M., Moaddab S. R., Sahebi L., Khalili M., et al. Vitamin D receptor gene polymorphism and vitamin d plasma concentration: correlation with susceptibility to tuberculosis. Adv Pharm Bull 4(Suppl. 2): 2014, 607–11.

Huang SJ, Wang XH, Liu ZD, Cao WL, Han Y, Ma AG, Xu SF. Vitamin D deficiency and the risk of tuberculosis: a meta-analysis. Drug Des Devel Ther. 2016 Dec 28;11:91-102.

Domingo-Gonzalez R, Prince O, Cooper A, Khader SA. Cytokines and Chemokines in Mycobacterium tuberculosis Infection. Microbiol Spectr. 2016 Oct;4(5):10.1128/microbiolspec.

Reichler MR, Hirsch C, Yuan Y, Khan A, et al. Tuberculosis Epidemiologic Studies Consortium Task Order 2 Team. Predictive value of TNF-α, IFN-γ, and IL-10 for tuberculosis among recently exposed contacts in the United States and Canada. BMC Infect Dis. 2020 Jul 31;20(1):553.

Wu F, Qu Y, Tang Y, Cao D, Sun P, Xia Z. Lack of association between cytokine gene polymorphisms and silicosis and pulmonary tuberculosis in Chinese iron miners. J Occup Health. 2008;50(6):445-54.

Selvaraj P, Sriram U, Mathan Kurian S, Reetha AM, Narayanan PR. Tumour necrosis factor alpha (-238 and -308) and beta gene polymorphisms in pulmonary tuberculosis: haplotype analysis with HLA-A, B and DR genes. Tuberculosis. 2001;81(5-6):335-41.

Delgado JC, Baena A, Thim S, Goldfeld AE. Ethnic-specific genetic associations with pulmonary tuberculosis. J Infect Dis. 2002 Nov 15;186(10):1463-8.

Scola L, Crivello A, Marino V, Gioia V, et al. IL-10 and TNF-alpha polymorphisms in a sample of Sicilian patients affected by tuberculosis: implication for ageing and life span expectancy. Mech Ageing Dev. (2003) 124:569–72.

Correa PA, Gomez LM, Cadena J, Anaya JM. Autoimmunity and TB. Opposite association with TNF polymorphism. J Rheumatol. (2005) 32:219–24.

Jafari M, Nasiri MR, Sanaei R, Anoosheh S, et al. The NRAMP1, VDR, TNF-alpha, ICAM1, TLR2 and TLR4 gene polymorphisms in Iranian patients with pulmonary tuberculosis: A case-control study. Infect Genet Evol. (2016) 39:92–8.

Yi YX, Han JB, Zhao L, Fang Y, Zhang YF, Zhou GY. Tumor necrosis factor alpha gene polymorphism contributes to pulmonary tuberculosis susceptibility: evidence from a meta-analysis. Int J Clin Exp Med. (2015) 8:20690–700.

Li X, Yang Y, Zhou F, Zhang Y, Lu H, Jin Q, Gao L. SLC11A1 (NRAMP1) polymorphisms and tuberculosis susceptibility: updated systematic review and meta- analysis. PLoS One. 2011 Jan 25;6(1):e15831.

Malik S, Abel L, Tooker H, Poon A, et al. Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis disease. Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12183-8.

Alcaïs A, Quintana-Murci L, Thaler DS, Schurr E, Abel L, Casanova JL. Life-threatening infectious diseases of childhood: single-gene inborn errors of immunity? Ann N Y Acad Sci. 2010 Dec;1214:18-33.

Mao X, Ke Z, Liu S, Tang B, Wang J, Huang H, Chen S. IL-1β+3953C/T, -511T/C and IL-6 -174C/G polymorphisms in association with tuberculosis susceptibility: A meta-analysis. Gene. 2015 Nov 15;573(1):75-83.

Trajkov D, Trajchevska M, Arsov T, et al. Association of 22 cytokine gene polymorphisms with tuberculosis in Macedonians. Indian J Tuberc. 2009 Jul;56(3):117-31.

Selvaraj P, Alagarasu K, Harishankar M, et al. Cytokine gene polymorphisms and cytokine levels in pulmonary tuberculosis. Cytokine. 2008 Jul;43(1):26-33.

Akgunes A, Coban AY, Durupinar B. Human leucocyte antigens and cytokine gene polymorphisms and tuberculosis. Indian J Med Microbiol. 2011 Jan- Mar;29(1):28-32.

Amirzargar AA, Rezaei N, Jabbari H, et al. Cytokine single nucleotide polymorphisms in Iranian patients with pulmonary tuberculosis. Eur Cytokine Netw. 2006 Jun;17(2):84-9.

Abhimanyu; Bose M, Jha P. Indian Genome Variation Consortium. Footprints of genetic susceptibility to pulmonary tuberculosis: cytokine gene variants in north Indians. Indian J Med Res. 2012 May;135(5):763-70.

Vidyarani M, Selvaraj P, Prabhu Anand S, et al. Interferon gamma (IFNgamma) & interleukin-4 (IL-4) gene variants & cytokine levels in pulmonary tuberculosis. Indian J Med Res. 2006 Oct;124(4):403-10.

Singh PP, Goyal A. Interleukin-6: a potent biomarker of mycobacterial infection. Springerplus. 2013 Dec 21;2:686.

Baker AR, Zalwango S, Malone LL, et al. Genetic susceptibility to tuberculosis associated with cathepsin Z haplotype in a Ugandan household contact study. Hum Immunol. 2011 May;72(5):426-30.

Larcombe LA, Orr PH, Lodge AM, et al. Functional gene polymorphisms in canadian aboriginal populations with high rates of tuberculosis. J Infect Dis. 2008 Oct 15;198(8):1175-9.

Ansari A, Hasan Z, Dawood G, Hussain R. Differential Combination of Cytokine and Interferon- γ +874 T/A Polymorphisms Determines Disease Severity in Pulmonary Tuberculosis. PLoS ONE, 2011, 6(11): e27848.

Roodposhti S., Motalleb G., Nikokar I. Rs4073 single nucleotide polymorphism of interleukin-8 (CXCL8/IL-8) and susceptibility to pulmonary tuberculosis in Gilan, Northern Iran. Gene Reports. 2018, (11):127-130.

Ma Y, Liu YH, Zhang ZG, Wang L, et al. Interleukin 8 Gene Polymorphisms Are Not Associated with Tuberculosis Susceptibility in the Chinese Population. Biomed Environ Sci. 2016 Feb;29(2):158-61.

Hu Q, Hua H, Zhou L, Zou X. Association between interleukin-8 -251A/T polymorphism and the risk of tuberculosis: A meta-analysis. J Int Med Res. 2020 May;48(5):300060520917877.

O’Leary S, O’Sullivan MP, Keane J. IL-10 blocks phagosome maturation in mycobacterium tuberculosis- infected human macrophages. Am J Respir Cell Mol Biol. 2011 Jul;45(1):172-80.

Scola L, Crivello A, Marino V, et al. IL-10 and TNF- alpha polymorphisms in a sample of Sicilian patients affected by tuberculosis: implication for ageing and life span expectancy. Mech Ageing Dev. 2003 Apr;124(4):569-72.

Henao MI, Montes C, París SC, García LF. Cytokine gene polymorphisms in Colombian patients with different clinical presentations of tuberculosis. Tuberculosis (Edinb). 2006 Jan;86(1):11-9.

Meenakshi P, Ramya S, Shruthi T, et al. Association of IL-1β +3954 C/T and IL-10-1082 G/A cytokine gene polymorphisms with susceptibility to tuberculosis. Scand J Immunol. 2013 Jul;78(1):92-7.

Lindenau JD, Guimarães LS, Friedrich DC, et al. Cytokine gene polymorphisms are associated with susceptibility to tuberculosis in an Amerindian population. Int J Tuberc Lung Dis. 2014 Aug;18(8):952-7.

Prabhu Anand S, Selvaraj P, Jawahar MS, et al. Interleukin-12B & interleukin-10 gene polymorphisms in pulmonary tuberculosis. Indian J Med Res. 2007 Aug;126(2):135-8.

Ates O, Musellim B, Ongen G, Topal-Sarikaya A. Interleukin-10 and tumor necrosis factor-alpha gene polymorphisms in tuberculosis. J Clin Immunol. 2008 May;28(3):232-6.

Vacaflores A, Freedman SN, Chapman NM, Houtman JC. Pretreatment of activated human CD8 T cells with IL-12 leads to enhanced TCR-induced signaling and cytokine production. Mol Immunol. 2017 Jan;81:1-15.

Freidin MB, Rudko AA, Kolokolova OV, et al. Association between the 1188 A/C polymorphism in the human IL12B gene and Th1-mediated infectious diseases. Int J Immunogenet. 2006 Jun;33(3):231-2.

Morahan G, Kaur G, Singh M, et al. Association of variants in the IL12B gene with leprosy and tuberculosis. Tissue Antigens. 2007 Apr;69 Suppl 1:234-6.

Morris GA, Edwards DR, Hill PC, Wejse C, et al. Interleukin 12B (IL12B) genetic variation and pulmonary tuberculosis: a study of cohorts from The Gambia, Guinea-Bissau, United States and Argentina. PLoS One. 2011 Feb 9;6(2):e16656.

Remus N, El Baghdadi J, Fieschi C, et al. Association of IL12RB1 polymorphisms with pulmonary tuberculosis in adults in Morocco. J Infect Dis. 2004 Aug 1;190(3):580-7.

Kusuhara K, Yamamoto K, Okada K, et al. Association of IL12RB1 polymorphisms with susceptibility to and severity of tuberculosis in Japanese: a gene-based association analysis of 21 candidate genes. Int J Immunogenet. 2007 Feb;34(1):35-44

Lee HW, Lee HS, Kim DK, et al. Lack of an association between interleukin-12 receptor beta1 polymorphisms and tuberculosis in Koreans. Respiration. 2005 Jul- Aug;72(4):365-8.

McHenry ML, Bartlett J, Igo RP Jr, et. al. Interaction between host genes and Mycobacterium tuberculosis lineage can affect tuberculosis severity: Evidence for coevolution? PLoS Genet. 2020 Apr 30;16(4):e1008728.

Soedarsono S, Amin M, Tokunaga K, et al. Association of disease severity with toll-like receptor polymorphisms in multidrug-resistant tuberculosis patients. Int J Mycobacteriol. 2020 Oct- Dec;9(4):380-390.

Torrado E, Cooper AM. IL-17 and Th17 cells in tuberculosis. Cytokine Growth Factor Rev. 2010 Dec;21(6):455-62.

Yu ZG, Wang BZ, Li J, et al. Association between interleukin-17 genetic polymorphisms and tuberculosis susceptibility: an updated meta-analysis. Int J Tuberc Lung Dis. 2017 Dec 1;21(12):1307-1313.

Schneider BE, Korbel D, Hagens K, et al. A role for IL-18 in protective immunity against Mycobacterium tuberculosis. Eur J Immunol. 2010 Feb;40(2):396-405.

Zhen LB, Sun YP, Chen YY, Yin LS. IL-18 polymorphisms and tuberculosis susceptibility: a meta-analysis. Afr Health Sci. 2019 Mar;19(1):1311- 1320.

He C, Liu L. Associations of polymorphisms in IL-6 and IL-18 with tuberculosis: Evidence from a meta- analysis. Microb Pathog. 2020 Feb;139:103823.

Saukkonen JJ, Bazydlo B, Thomas M, et al. Beta-chemokines are induced by Mycobacterium tuberculosis and inhibit its growth. Infect Immun. 2002 Apr;70(4):1684-93.

Chu SF, Tam CM, Wong HS, et al. Association between RANTES functional polymorphisms and tuberculosis in Hong Kong Chinese. Genes Immun. 2007 Sep;8(6):475-9.

Ben-Selma W, Harizi H, Bougmiza I, et al. Polymorphisms in the RANTES gene increase susceptibility to active tuberculosis in Tunisia. DNA Cell Biol. 2011 Oct;30(10):789-800.

Kouhpayeh HR, Taheri M, Baziboroon M, et al. CCL5 rs2107538 Polymorphism Increased the Risk of Tuberculosis in a Sample of Iranian Population. Prague Med Rep. 2016;117(2-3):90-97.

Varzari A, Tudor E, Bodrug N, Corloteanu A, Axentii E, Deyneko IV. Age-Specific Association of CCL5 Gene Polymorphism with Pulmonary Tuberculosis: A Case-Control Study. Genet Test Mol Biomarkers. 2018 May;22(5):281-287.

Antony BS, Nagarajan C, Thomas KE, Stephen SB, et al. IFN-gene polymorphisms as a risk factor for tuberculosis infection in Asian populations: A meta-analysis. Int J Mycobacteriol. 2023 Jul- Sep;12(3):226-234.

Lio D, Marino V, Serauto A, Gioia V, et al. Genotype frequencies of the +874T-->A single nucleotide polymorphism in the first intron of the interferon- gamma gene in a sample of Sicilian patients affected by tuberculosis. Eur J Immunogenet. 2002 Oct;29(5):371-4.

Ansari A, Talat N, Jamil B, Hasan Z, et al. Cytokine gene polymorphisms across tuberculosis clinical spectrum in Pakistani patients. PLoS One. 2009;4(3):e4778.

Rossouw M, Nel HJ, Cooke GS, van Helden PD, Hoal EG. Association between tuberculosis and a polymorphic NFkappaB binding site in the interferon gamma gene. Lancet. 2003 May 31;361(9372):1871-2.

López-Maderuelo D, Arnalich F, Serantes R, et al. Interferon-gamma and interleukin-10 gene polymorphisms in pulmonary tuberculosis. Am J Respir Crit Care Med. 2003 Apr 1;167(7):970-5.

Tso HW, Ip WK, Chong WP, et al.. Association of interferon gamma and interleukin 10 genes with tuberculosis in Hong Kong Chinese. Genes Immun. 2005 Jun;6(4):358-63.

Pacheco AG, Cardoso CC, Moraes MO. IFNG +874T/A, IL10 -1082G/A and TNF -308G/A polymorphisms in association with tuberculosis susceptibility: a meta-analysis study. Hum Genet. 2008 Jun;123(5):477-84.

Moran A, Ma X, Reich RA, Graviss EA. No association between the +874T/A single nucleotide polymorphism in the IFN-gamma gene and susceptibility to TB. Int J Tuberc Lung Dis. 2007 Jan;11(1):113-5.

Cooke GS, Campbell SJ, Sillah J, et al. Polymorphism within the interferon-gamma/receptor complex is associated with pulmonary tuberculosis. Am J Respir Crit Care Med. 2006 Aug 1;174(3):339-43.

Shin JG, Park BL, Kim LH, Namgoong S, et al. Association study of polymorphisms in interferon-γ receptor genes with the risk of pulmonary tuberculosis. Mol Med Rep. 2015 Jul;12(1):1568-78.

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2025-09-09

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