Морфофункциональные нарушения эритроцитов у больных ожирением с инфекцией SARS- CoV-2
DOI:
https://doi.org/10.52692/1857-0011.2025.2-82.18Аннотация
Введение. У лиц с ожирением и с COVID-19 были выявлены метаболические нарушения. Цель исследования: Выявить морфофункциональные изменения показателей эритроцитарных индексов MCH и RDW, уровни эритроцитов и ферритина в сыворотке крови у пациентов с ожирением, больных COVID-19. Материалы и методы. Обследованные 44 пациента: мужчин - 27 (61.62%), женщин - 17 (38.8%), средний возраст 55.16±4.5 лет были разделены на 4 группы: Группа I (n=9) пациенты с индексом массы тела (ИМТ) 30 -34.9 кг/м², Гр. II (n=8) - ИМТ=35 - 39.9, Гр. III (n=10) с ИМТ>40 кг/м², группа сравнения (Гр. к) (n=17) пациенты с COVID-19,с нормальным весом. Степень ожирения определяли по значению индекса массы тела (ИМТ) - отношение массы тела в килограммах к квадрату роста в метрах (кг/м²).Полученные результаты. Эритроциты выявлены в Гр. I - 4.67±0.16, p≥0.05 во Гр. II - 4.82±0.1 p≤0.05,в Гр. III4.82±0.2, p≥0.05, в сравнении с Гр. к. - 4.68±0.13 (106/ul), Индекс RDW максимально увеличен в Гр. III - 13±0,3, p≤0.05, во Гр. II - 12.7±0.13, p≤0.01в Гр. I - 12±0.3, p≤0.05, в сравнении с Гр. к. - 12.15±0.14 (%).Выводы. Результаты проведенных исследований подтверждают наличие морфофункциональных нарушений эритроцитов и эритроцитарных индексов при повышении уровня сывороточного ферритина у больных ожирением с COVID-19, прямо пропорционально увеличению индекса массы тела.
Библиографические ссылки
Gharebaghi R, Heidary F. COVID-19 and Iran: swimming with hands tied!. Swiss Med Wkly. 2020;150:w20242.
Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239-1242.
Louisiana Department of Health. Louisiana Department of Health Updates for 3/31/2020. Accessed April 6, 2020. http://ldh.la.gov/index.cfm/ newsroom/detail/5522
Centers for Disease Control and Prevetion (CDC). Obesity worsens outcomes from COVID-19; 2020. Available from: https://www.cdc.gov/obesity/data/ obesity-and-covid-19.html
Flint SW, Tahrani AA. COVID-19 and obesity-lack of clarity, guidance, and implications for care. Lancet Diabetes Endocrinol. 2020;8(6):474-475.
Hendren NS, de Lemos JA, Ayers C, et al. Association of Body Mass Index and Age With Morbidity and Mortality in Patients Hospitalized With COVID-19: Results From the American Heart Association COVID-19 Cardiovascular Disease Registry. Circulation. 2021;143(2):135-144.
van der Voort PHJ, Moser J, Zandstra DF, et al. Leptin levels in SARS-CoV-2 infection related respiratory failure: A cross-sectional study and a pathophysiological framework on the role of fat tissue. Heliyon. 2020;6(8):e04696.
Richardson S, Hirsch JS, Narasimhan M, et al. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA. 2020;323(20):2052-2059.
Ryan PM, Caplice NM. Is Adipose Tissue a Reservoir for Viral Spread, Immune Activation, and Cytokine Amplification in Coronavirus Disease 2019? Obesity (Silver Spring). 2020;28(7):1191-1194.
de Lucena TMC, da Silva Santos AF, de Lima BR, et al. Mechanism of inflammatory response in associated comorbidities in COVID-19. Diabetes Metab Syndr. 2020;14(4):597-600.
Zhang H, Penninger JM, Li Y, et al. Angiotensin- convertingenzyme 2 (ACE2) asa SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive Care Med. 2020;46(4):586-590.
Khawaja UA, Shamsoddin E, Desideri LF, et al. Infection of red blood cells by SARS-CoV-2: new evidence. Einstein (Sao Paulo). 2021;19:eCE6285.
Kwaifa IK, Bahari H, Yong YK, et al. Endothelial Dysfunction in Obesity-Induced Inflammation: Molecular Mechanisms and Clinical Implications. Biomolecules. 2020;10(2):291.
Renoux C, Fort R, Nader E, et al. Impact of COVID-19 on red blood cell rheology. Br J Haematol. 2021;192(4):e108-e111.
Park J, Foox J, Hether T, et al. System-wide transcriptome damage and tissue identity loss in COVID-19 patients. Cell Rep Med. 2022;3(2):100522.
Weiss G, Ganz T, Goodnough LT. Anemia of inflammation. Blood. 2019;133(1):40-50.
WHO: “Obesity and overweight”. https://www. who.int/news-room/fact-sheets/detail/obesity-and- overweight
Priesemann V, Balling R, Brinkmann MM, et al. An action plan for pan-European defence against new SARS-CoV-2 variants. Lancet. 2021;397(10273):469- 470.
Curocichin Gh, Șalaru V, Gîțu L. Protocolul clinic standardizet pentru medicii de familie. Infecția cu coronavirus de tip nou COVID-19. Pentru aplicare în cazul de sfășurării Scenariului 3 din Planul de pregătire și răspuns, la infecţia cu coronavirus de tip nou COVID-19, Chișinău, 2020, 6 p.
Lupașco I, Tcaciuc E, Dumbrava V.-T, et al. Ghid de conduită a pacienților cu boli crоnice difuze hepatice în condiții de pandemie cu Covid-19. Edițiaa II-a. Chișinău: CEP Medicina, 2022; 130 p. ISBN 978- 9975-82-243-5.
Ghelimici T, Lupașco Iu, Harea G, et al. Dereglări morfofuncționale ale eritrocitelor la pacienții obezi cu Covid-19. Conferința științifică internațională, ediția a IX-a Femeile în cercetare: destine, contribuții, perspective” 8-9 februarie 2024.pp169-170.
Lorente L, Martín MM, Argueso M, et al. Association between red blood cell distribution width and mortality of COVID-19 patients. Anaesth Crit Care Pain Med. 2021;40(1):100777.
Dhinata K. Common Change of Complete Blood Count Parameters in COVID-19: A Literature Review. J. Med. Health. 2021;3:198–207.
Williamson EJ, Walker AJ, Bhaskaran K, et al. Factors associated with COVID-19-related death using OpenSAFELY. Nature. 2020;584(7821):430-436.
PetelinaT.I, Musikhina N.A. et al. The study of the dynamics of clinical and laboratory-instrumental parameters in hypertensive patients with obesity who underwent COVID-19-associated pneumonia. Obesity and metabolism. 2022;19(4):387-395.
Russo A, Tellone E, Barreca D, et al. Implication of COVID-19 on Erythrocytes Functionality: Red Blood Cell Biochemical Implications and Morpho- Functional Aspects. Int J Mol Sci. 2022;23(4):2171.
Bergamaschi G, Borrelli de Andreis F, et al. Anemia in patients with Covid-19: pathogenesis and clinical significance. Clin Exp Med. 2021 May;21(2):239-246.
Abdalla S, Farsaci F, Tellone E, et al. Hemoglobin glycation increases the electric charges on red blood cells: Effects of dielectric polarization. Mater. Chem. Phys.2022;276:125348.
Kaushal K, Kaur H, Sarma P, et al. Serum ferritin as a predictive biomarker in COVID-19. A systematic review, meta-analysis and meta-regression analysis. J Crit Care. 2022;67:172-181.
Cheng L, Li H, Li L, et al. Ferritin in the coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis. J Clin Lab Anal. 2020;34(10):e23618.
Lee JJ, Montazerin SM, Jamil A, et al. Association between red blood cell distribution width and mortality and severity among patients with COVID-19: A systematic review and meta-analysis. J Med Virol. 2021;93(4):2513-2522.
Henry BM, Benoit JL, Benoit S, et al. Red Blood Cell Distribution Width (RDW) Predicts COVID-19 Severity: A Prospective, Observational Study from the Cincinnati SARS-CoV-2 Emergency Department Cohort. Diagnostics (Basel). 2020;10(9):618. Published 2020 Aug 21.
Thomas T, Stefanoni D, Dzieciatkowska M, et al. Evidence of Structural Protein Damage and Membrane Lipid Remodeling in Red Blood Cells from COVID-19 Patients. J Proteome Res. 2020;19(11):4455-4469.
Загрузки
Опубликован
Лицензия
Copyright (c) 2026 Вестник Академии Наук Молдовы. Медицина
Это произведение доступно по лицензии Creative Commons «Attribution» («Атрибуция») 4.0 Всемирная.
