The management of brain tumors at children
Keywords:tumor, obstructive hydrocephalus, morbidity structure, сomplications
AbstractBackground: Brain tumors are a severe form of pathologies, that are more common in children and it is associated with hydrocephali. The long term effects of central nervous system therapy for children with brain tumors have been the subject of research since the 1970. Many studies have demonstrated that children treated for brain tumors with surgery and standard radiation therapy have developed intellectual decline which is progressive over at least a decade. Risk factors for the cognitive deterioration have been identified and include: perioperative complications, hydrocephalus, high radiation dose, large volume radiation, chemotherapy (especially methotrexate), vasculopaty and young age at the time of treatment. The purpose of research: Study of surgical treatment applied to children with brain tumors hydrocephalus by implementing and perfecting the surgical treatment. Material and methods: We used data of 2018-2019 period, in the Children Clinical Hospital „V. Ignatenco”, of the Republic of Moldova, which shows the structure of morbidity through malign and benign tumors with associated hydrocephalus at prematures population. Results: Since 2018-2019 were diagnosed 13 children. The average age was: 1 child(0,76 %) 0-1 years old, 5 children (38,46 %) 2-5 years old, 2 children (15,38 %) 6-10 years old and 5 children (38,46 %)11-17 years old. From 13 children, 2 children (15,38 %) were inoperable. The incidence was 10 boys (76,92%) and 3 girls (23,07%). There were complications: malign hipertermia, anemia, cranial nerves damages (facial asymmetry, palpebral ptosis), hemiparesis, intraventricular bleeding. Conclusions: The morbidity was common in boys, average age was 2-5 and 11-17 years old. Chidrenswere operated in two ways. There were complications since intraoperatory and postoperatory period
Revista română de pediatrie – vol. LVI, nr. 4, an. 2007
Blaney S.M., Larry E.K., Hunter J. et al – Tumors of the central nervous system. In: Pizzo P A, Poplack DG (eds) Principles and practice of Pediatric Oncology (5 thedn) Philadelphia, PA: JB Lippincott, 786864, 2006.
Cohen M.E., Duffner P.K. (eds) – Brain Tumors in Children. Principles of Diagnosis and Treatment (2nd edn) New York: Raven Press, 1994, 127-46,177-201, 21939, 445-481
Dufner PK, Korowitz ME, Krischer JP et al. – The treatment of malignant brain tumors in infants and very young children: an update of the Pediatric Oncology Group experience. Neurooncology, 1999, 1, 152-161.
Freemen C.R., Taylor R.E., Kortmann R.D., Carrie C. – Radiotherapy for medulloblastoma in children: a perspective on current international clinical research efforts. Med Pedatr. Oncol, 2002, 39, 99-108
Gotzer M.A., Janss A.J., Fung K.M. et al – TrkC expression predicts good clinical outcome in primitive neuroectodermal brain tumors. J Clin Oncol, 2000, 18, 1027-1035.
Herms J., Neidt I., Luscher B. et al – c-myc expression in meduloblastoma and his prognostic value. Int J Cancer, 2000, 395-402
Pomeroy S.L., Tamayo P., Gaasenbeck M. et al.– Prediction of central nervous system embrional tumor outcome based on gene expression. Nature, 2002, 415, 436-442
Heckl, Aschoff A., Kunze S. – Radiation-induced cavernous hemangiomas of the brain: a late effect predominantly in children. Cancer, 2002, 94, 3285-3291.
Kleihues P., Cavenee W.K. (eds) – Pathology and genetics of tumors of the Nervous System. Lyon: IARC (2000).
Ko J.K., Cha S.H., Choi B.K., Lee J.I., Yun E.Y., Choi C.H. „Hemorrhage Rates Associated with Two Methods of Ventriculostomy: External Ventricular Drainage vs Ventriculoperitoneal shunt procedure”. Neurol Med Chir (Tokyo).2014 Feb10.
Lo W.B., Ramirez R., Rodrigues D., Solanki G.A.„Ventriculoperitoneal shunt disconnection associated with spontaneous knot formation in the peritoneal catheter”. BMJ Case Rep. 2013 May
Kortmann R.D., Kuhl J., Timmermann B. et al. – Current and futures strategies in interdisciplinary treatment of medulloblastoma, supratentorial PNET (primitive neuroectoderman tumors) and intracranial germ cell tumors in childhood. Strahlenther Onkol, 2001, 177, 447-461.
Mandiwanza T., Kaliaperumal C., Caird J. „Central brain herniation in shunted Dandy Walker cyst”. Childs Nerv Syst. 2013 Jun;
Mattei T.A., Salma A., Lin J.J. „Spontaneous bowel perforation from distal catheter leading to meningitis: a rare but frequently overlooked complication of ventriculoperitoneal shunts”. Pediatr Neurol. 2013 Jun
Matsubara T., Ayuzawa S., Aoki T., Ikeda G., Shiigai M., Matsumura A. Neurol Med Chir (Tokyo).„Cerebral venous thrombosis after ventriculoperitoneal shunting: a case report”. Neurol Med Chir (Tokyo). 2013 Nov 20.
Meier U., Stengel D., Müller C., Fritsch M.J., Kehler U., Langer N., Kiefer M., Eymann R., Schuhmann M.U., Speil A., Weber F., Remenez V., Rohde V,. Ludwig H.C., Lemcke „Predictors of subsequent overdrainage and clinical outcomes after ventriculoperitoneal shunting for idiopathic normal pressure hydrocephalus. J. Neurosurgery. 2013 Dec;73(6): 1054-1060.
Michaelis J., Kaletsch U., Kaatsch P. – Epidemiology of childhood brain tumour. ZentralblNeurochir, 2000, 61, 80-87.
Mulhern R.K., Reddick W.E., Palmer S.L. et al. – Neurocognitive deficits in medulloblastoma survivors and white matter loss. Ann Neurol, 1999, 46, 834-841.
Radcliffe J., Bunin G.R., Sutton L.N. et al. – Cognitive deficits in long term survivors of childhood medulloblastoma and other non-cortical tumors: age dependent effects of whole brain irradiation. Int J Dev Neurosci, 1994, 12, 327-334
Siffert J., Allen J.K. – Late effects of therapy of thalamic and hypothalamic tumors in childhood: vascular, neurobehavioural and neoplastic. Pediatr. Neurosurg, 2000, 33, 105-111.
Гогорян С. Ф. и др. Опухоли головного мозга, сочетающиеся с гидроцефалией. В: Журнал Вопросы нейрохирургии им. Н.Н. Бурденко, 2008, № 4, с. 39-42.
Copyright (c) 2021 Bulletin of the Academy of Sciences of Moldova. Medical Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.