Impact of comorbidities on chronic obstructive pulmonary disease (literature review)

Authors

  • Ecaterina STAVILA Discipline of pulmonology and Allergology, Department of Internal Medicine, IP State University of Medicine and pharmacy "Nicolae Testemitanu", Chisinau, Republic Of Moldova; IMSP Institute of Phthisiopneumology "Chiril Draganiuc", Chisinau, Republic Of Moldova
  • Victor BOTNARU Discipline of pulmonology and Allergology, Department of Internal Medicine, IP State University of Medicine and pharmacy "Nicolae Testemitanu", Chisinau, Republic Of Moldova;
  • Alexandru CORLATEANU Дисциплина пневмологии и аллергологии, Департамент внутренней медицины, ИП государственный университет медицины и фармации им. Николае Тестемицану, Кишинев, Республика Молдова;

DOI:

https://doi.org/10.52692/1857-0011.2021.3-71.46

Keywords:

comorbidities, multimorbidity, chronic obstructive pulmonary disease, multidimensional indices

Abstract

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Multimorbidity is the presence of two or more chronic conditions in a person at the same time. Multimorbidity is frequently associated in patients with COPD and is a modifiable key factor, which requires timely identification and holistic managementstrategies, aimed at improving outcomes and reducing the burden of disease. Diagnosis and assessment of the severity ofCOPD can be difficult in the presence of comorbid conditions. Comorbidities increase in number and severity with thepatient’s age and have a major impact on quality of life, hospitalization and direct mortality.Finally, we will focus on current management strategies with the goal of a holistic, patient-centered approach rather than single disease management.
This literature review provides an overview of the impact of comorbidities on chronic obstructive pulmonary disease

Author Biographies

Victor BOTNARU, Discipline of pulmonology and Allergology, Department of Internal Medicine, IP State University of Medicine and pharmacy "Nicolae Testemitanu", Chisinau, Republic Of Moldova;

dr. hab. în șt. med., prof. univer.

Alexandru CORLATEANU, Дисциплина пневмологии и аллергологии, Департамент внутренней медицины, ИП государственный университет медицины и фармации им. Николае Тестемицану, Кишинев, Республика Молдова;

dr. hab. în șt. med., conf. univer

References

Corlateanu, A., N. Siafakas, and V. Botnaru, Defining COPD: from simplistic approach to multilateral assessment of COPD. Current Respiratory Care Reports, 2012. 1(3): p. 177-182.

Vogelmeier, C.F., et al., Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report. GOLD Executive Summary. Am J Respir Crit Care Med, 2017. 195(5): p. 557-582.

Corlăţeanu, A., et al., From smoking to COPD--current approaches. Pneumologia, 2016. 65(1): p. 20-3.

Lamprecht, B., et al., COPD in never smokers: results from the population-based burden of obstructive lung disease study. Chest, 2011. 139(4): p. 752-763.

Gut-Gobert, C., et al., Women and COPD: do we need more evidence? European Respiratory Review, 2019. 28(151): p. 180055.

Corlateanu, A., et al., Prevalence and burden of comorbidities in Chronic Obstructive Pulmonary Disease.Respir Investig, 2016. 54(6): p. 387-396.

Agusti, A., Thomas a. Neff lecture. Chronic obstructive pulmonary disease: a systemic disease. Proc Am Thorac Soc, 2006. 3(6): p. 478-81.

Casaburi, R., Skeletal muscle function in COPD. Chest, 2000. 117(5 Suppl 1): p. 267S-71S.

Morley, J.E., D.R. Thomas, and M.M. Wilson, Cachexia: pathophysiology and clinical relevance. Am J Clin Nutr, 2006. 83(4): p. 735-43.

Sin, D.D. and S.F. Man, Chronic obstructive pulmonary disease as a risk factor for cardiovascular morbidity and mortality. Proc Am Thorac Soc, 2005. 2(1): p. 8-11.

Chaouat, A., R. Naeije, and E. Weitzenblum, Pulmonary hypertension in COPD. Eur Respir J, 2008. 32(5):p. 1371-85.

Mallia, P. and S.L. Johnston, How viral infections cause exacerbation of airway diseases. Chest, 2006.130(4): p. 1203-10.

Bolton, C.E., et al., Associated loss of fat-free mass and bone mineral density in chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2004. 170(12): p. 1286-93.

Brody, J.S. and A. Spira, State of the art. Chronic obstructive pulmonary disease, inflammation, and lung cancer. Proc Am Thorac Soc, 2006. 3(6): p. 535-7.

Sarkar, M., P.N. Rajta, and J. Khatana, Anemia in Chronic obstructive pulmonary disease: Prevalence, pathogenesis, and potential impact. Lung India, 2015. 32(2): p. 142-51.

Soler, X., et al., High Prevalence of Obstructive Sleep Apnea in Patients with Moderate to Severe Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc, 2015. 12(8): p. 1219-25.

Martinez-Garcia, M.A. and M. Miravitlles, Bronchiectasis in COPD patients: more than a comorbidity? Int J Chron Obstruct Pulmon Dis, 2017. 12: p. 1401-1411.

Yohannes, A.M. and G.S. Alexopoulos, Depression and anxiety in patients with COPD. Eur Respir Rev,2014. 23(133): p. 345-9.

Agusti, A. and J.B. Soriano, COPD as a systemic disease. COPD, 2008. 5(2): p. 133-8.

Steuten, L.M., et al., COPD as a multicomponent disease: inventory of dyspnoea, underweight, obesity and fat free mass depletion in primary care. Prim Care Respir J, 2006. 15(2): p. 84-91.

Yanbaeva, D.G., et al., Systemic effects of smoking. Chest, 2007. 131(5): p. 1557-66.22. Sinden, N.J. and R.A. Stockley, Chronic obstructive pulmonary disease: an update of treatment related to frequently associated comorbidities. Ther Adv Chronic Dis, 2010. 1(2): p. 43-57.

Sin, D.D., L. Wu, and S.F. Man, The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literature. Chest, 2005. 127(6): p. 1952-9.

Van Remoortel, H., et al., Risk factors and comorbidities in the preclinical stages of chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2014. 189(1):p. 30-8.

Barnett, K., et al., Epidemiology of multimorbidityand implications for health care, research, and medical education: a cross-sectional study. Lancet, 2012. 380(9836):p. 37-43.

Sullivan, P.W., et al., Obesity, inactivity, and the prevalence of diabetes and diabetes-related cardiovascular comorbidities in the U.S., 2000-2002. Diabetes Care, 2005. 28(7): p. 1599-603.

Gimeno-Santos, E., et al., Determinants and outcomes of physical activity in patients with COPD: a systematic review. Thorax, 2014. 69(8): p. 731-9.

O’Donnell, D.E. and K.A. Webb, The major limitation to exercise performance in COPD is dynamic hyperinflation. J Appl Physiol (1985), 2008. 105(2): p. 753-5; discussion 755-7.

Cooper, C.B., The connection between chronic obstructive pulmonary disease symptoms and hyperinflation and its impact on exercise and function. Am J Med, 2006. 119(10 Suppl 1): p. 21-31.

Mora, S., et al., Association of physical activity and body mass index with novel and traditional cardiovascular biomarkers in women. JAMA, 2006. 295(12): p. 1412-9.

Ito, K. and P.J. Barnes, COPD as a disease of accelerated lung aging. Chest, 2009. 135(1): p. 173-180.

Savale, L., et al., Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2009. 179(7): p. 566-71.

Uijen, A.A. and E.H. van de Lisdonk, Multimorbidity in primary care: prevalence and trend over the last 20 years. Eur J Gen Pract, 2008. 14 Suppl 1: p. 28-32.

Fortin, M., et al., A systematic review of prevalence studies on multimorbidity: toward a more uniform methodology. Ann Fam Med, 2012. 10(2): p. 142-51.

Sin, D.D., et al., Mortality in COPD: Role of comorbidities. Eur Respir J, 2006. 28(6): p. 1245-57.

Corlateanu, A., et al., Multidimensional indices in the assessment of chronic obstructive pulmonary disease. Respir Med, 2021. 185: p. 106519.

Divo, M., et al., Comorbidities and risk of mortality in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2012. 186(2): p. 155-61.

Published

2021-11-17

Issue

Section

Research Article