Consanguineous marriages as a risk factor for the development of primary bronchiectasis.
DOI:
https://doi.org/10.52692/1857-0011.2025.3-83.15Keywords:
bronchiectasis, consanguinity, consanguineous marriage, primary ciliary dyskinesia, cystic fibrosis, alpha-1 antitrypsin, CT, genetic testing, risk factorAbstract
Objective: To assess the impact of consanguinity on the development of primary bronchiectasis (BE). Methods: Single-center study of 163 patients with clinically and radiologically confirmed BE (2015–2025). Results: Primary BE was diagnosed in 112 (68.7%) patients; among them, parental consanguinity was documented in 69 cases (61.6%). Consanguinity was significantly more frequent in congenital (primary) vs post-infectious forms (χ²=47.5; p<0.0001). Patients with primary BE were younger (26.4±3.7 years) than those with secondary forms (32.1±4.1 years; p<0.05). Primary ciliary dyskinesia (~30%) and cystic lung hypoplasia (~19%) predominated among primary etiologies; cystic fibrosis cases showed more severe courses. Conclusion: Consanguinity is an important risk factor for genetically determined primary BE; systematic family history and molecular genetic testing should be incorporated into standard diagnostic pathways.
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